Possibilities for systemic enzyme therapy in patients with chronic endometritis after missed abortion


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Abstract

Objective. To evaluate the effectiveness of systemic enzyme therapy in patients with chronic endometritis after missed abortion on the basis of morphological and immunohistochemical studies. Materials and methods. The study included 37 reproductive-aged women with missed miscarriage. Wobenzym was used in rehabilitation therapy after artif icial abortion in 30 women. The conditions of the endometrium was studied by morphological and immunohistochemical methods before and after rehabilitation therapy. Results. The morphological signs of chronic inflammation were eliminated during the treatment with preparation Wobenzym; their elimination is confirmed by a decrease in the expression of HLA-DR and the disappearance of CD16+, CD20+, NK-lymphocytes and B-lymphocytes in the stroma. Indifferent endometrium in patients treated with Wobenzym was detected only in 6.7% of cases, secretory endometrium was detected in 73.3% of women, proliferative endometrium - in 26.7%. Conclusion. The use of Wobenzym after instrumental abortion in patients with endometritis and undeveloped pregnancy eliminates morphological signs of inflammation and promotes endometrial regeneration.

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About the authors

Irina M. Ordiyants

Peoples Friendship University of Russia, Ministry of Education and Science of Russia

Email: ordiyantc@mail.ru
Dr.Med.Sci., Professor, professor of the Department of Obstetrics and Gynecology with the course of Perinatology

Yevgenia A. Kogan

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia

Email: koganevg@gmail.com
Dr.Med.Sci., Professor, Head of the Department of Pathological Anatomy named after academician A.I. Strukov

Sofya S. Barabasheva

Peoples Friendship University of Russia, Ministry of Education and Science of Russia

Email: vurkina@list.ru
post-graduate student of the Department of Obstetrics and Gynecology with the course of Perinatology

Olga K. Molchanova

Peoples Friendship University of Russia, Ministry of Education and Science of Russia

Email: olgamolchanova1994@yandex.ru
resident of the Department of Obstetrics and Gynecology with the course of Perinatology

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