The use of aromatase inhibitors for rapid relief of ovarian hyperstimulation symptoms occurring with an in vitro fertilization program


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Abstract

Background. Despite the rather low incidence of severe ovarian hyperstimulation syndrome (OHSS) in IVF programs, this complication during its severe course negatively affects the health of young women, requires intensive and long-term treatment, and leads to pregnancy complications. In this connection, the issues of rapid relief of OHSS symptoms are extremely relevant, especially in patients planning to start gonadotoxic therapy immediately after ovarian stimulation and oocyte retrieval. Case report. There are two clinical cases describing and comparing the eff iciency of using aromatase inhibitors and gonadotropin-releasing hormone antagonists (GnRH-ant) for the rapid relief of ovarian hyperstimulation symptoms. Conclusion. The use of aromatase inhibitors versus GnRH-ant after transvaginal puncture contributes to a more rapid relief of the developed symptoms of ovarian hyperstimulation. It should be noted that the developed procedure is more cost effective than the use of GnRH-ant.

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About the authors

Yana O. Martirosyan

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: marti-yana@yandex.ru
Junior Researcher at the F. Paulsen SEC for ART

Tatiana A. Nazarenko

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: t_nazarenko@oparina4.ru
Dr. Med. Sci., professor, Head of the Institute of Reproductive Medicine

Irina E. Korneeva

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Dr. Med. Sci., Head of F. Paulsen SEC for ART

Almina M. Biryukova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: alma21@list.ru
MD, Candidate of Medical Sciences, doctor is in charge of clinical work of the Scientific and Educational Center for ART with the Clinical Division named after F. Paulsen

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