SPLENIC RUPTURE AS AN INAUGURAL MANIFESTATION OF MULTIMORBIDITY: ESSENTIAL THROMBOCYTHEMIA AND CONGENITAL THROMBOPHILIA


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Background. Essential thrombocythemia is a malignant myeloproliferative disease that can cause obstetric complications, such as severe preeclampsia, fetal growth restriction, miscarriage, postpartum hemorrhage, and multiple venous thromboses. Untimely diagnosis can lead to rupture of parenchymal organs, for example, spontaneous splenic rupture. Case report. The paper describes a clinical case of a pregnant woman with pregestationally undiagnosed congenital thrombophilia, essential thrombocythemia, which manifested itself during pregnancy as spontaneous splenic rupture and multiple venous thromboses. Conclusion. Timely diagnosis and adequate treatment in accordance with national clinical guidelines for the diagnosis and treatment of Ph-negative myeloproliferative diseases, including essential thrombocythemia (2016) and congenital thrombophilia, can ensure a favorable pregnancy outcome.

Full Text

Restricted Access

About the authors

Mikhail M. PADRUL

Academician E.A. Vagner Perm State Medical University, Ministry of Health of the Russian Federation

Email: m-padrul@mail.ru
Dr. Med. Sci., professor, Head of the Department of Obstetrics and Gynecology №1 Perm, Russian Federation

Vladimir G. ZHELOBOV

Academician E.A. Vagner Perm State Medical University, Ministry of Health of the Russian Federation

Email: zhelobov.vg@psma.ru
Dr. Med. Sci., professor, Head of the Department of Polyclinic Therapy Perm, Russian Federation

Gulnara K. SADYKOVA

Academician E.A. Vagner Perm State Medical University, Ministry of Health of the Russian Federation

Email: gulnara-sadykova@mail.ru
PhD, associate professor of the Department of Obstetrics and Gynecology №1 Perm, Russian Federation

Vera S. ZAPLATINA

Academician E.A. Vagner Perm State Medical University, Ministry of Health of the Russian Federation

Email: zaplatina-vera@mail.ru
associate professor of the Department of Obstetrics and Gynecology №1 Perm, Russian Federation

Ekaterina G. KOBAIDZE

Academician E.A. Vagner Perm State Medical University, Ministry of Health of the Russian Federation

Email: eka7i@yahoo.com
Dr. Med. Sci., associate professor of the Department of Obstetrics and Gynecology №1 Perm, Russian Federation

Anna A. VORONOVA

Academician E.A. Vagner Perm State Medical University, Ministry of Health of the Russian Federation

Email: voronova.anna96@yandex.ru
6th year student of the medical faculty Perm, Russian Federation

References

  1. Харкевич О.Н., Миров А.И. Роль наследственных и приобретенных тромбофилий в патогенезе самопроизвольного аборта и привычной потери беременности. Таврический медико-биологический вестник. 2015; 18(1): 127-31.
  2. Савицкая В.М., Ниделько А.А. Роль наследственной тромбофилии в невынашивании беременности. Альманах молодой науки. 2016; 4: 16-20.
  3. Гусина А.А., Гусина Н.Б. Наследственные тромбофилии и венозные тромбоэмболические осложнения в акушерстве. Репродуктивное здоровье. Восточная Европа. 2016; 6(3): 380-92.
  4. Меликян А.Л., Ковригина А.М., Суборцева И.Н., Шуваев В.А., Афанасьев Б.В., Агеева Т.А., Бойков В.В., Виноградова О.Ю., Голенков А.К., Грицаев С.В., Зарицкий А.Ю., Капланов К.Д., Ломаиа Е.Г., Мартынкевич И.С., Морозова Е.В., Поспелова Т.И., Соколова М.А., Судариков А.Б., Туркина А.Г., Шатохин Ю.В., Савченко В.Г. Национальные клинические рекомендации по диагностике и терапии Ph-негативных миелопролиферативных заболеваний (истинная полицитемия, эссенциальная тромбоцитемия, первичный миелофиброз. (Редакция 2018 г.). Гематология и трансфузиология, 2018. 3: 275-315.
  5. Puyade M., Cayssials E., Pierre F., Pourrai O. Pregnancy and myeloproliferative neoplasms: а retrospective monocentric cohort. Obstet. Med. 2017; 10(4): 165-9. https://dx.doi.org/10.1177/1753495X17708896.
  6. Матейкович Е.А., Шевлюкова Т.П., Кукарекая Е.Ю., Галиева Г.Д. Медицинские ошибки при оказании акушерско-гинекологической помощи. Современные проблемы науки и образования. 2018; 5: 196.
  7. Шевлюкова Т.П. Роль тромбоцитов в гемостазе. Тюмень: Вектор-Бук; 1999. 96 с.
  8. De Stefano V., Za T., Rossi E., Fiorini A., Ciminello A., Luzzi C. et al. Influence of the JAK2 V617F mutation and inherited thrombophilia on the thrombotic risk among patients with essential thrombocythemia. Haematologica. 2009; 94(5): 733-7. https://dx.doi.org/ 10.3324/haematol.13869.
  9. Gangat N., Wolanskyj A.P., Schwager S., Tefferi A. Predictors of pregnancy outcome in essential thrombocythemia: a single institution study of 63 pregnancies. Eur. J. Haematol. 2009; 82(5): 350-3. https://dx.doi.org/10.1111/ j.1600-0609.2009.01214.x.
  10. Frenkel E.P., Bick R.L. Prothrombin G20210A gene mutation, heparin cofactor II defects, primary (essential) thrombocythemia, and thrombohemorrhagic manifestations. Semin. Thromb. Hemost. 1999; 25(4): 375-86. https://dx.doi. org/10.1055/s-2007-994941.
  11. Галайко М.В., Рыбина О.В., Литвиненко М.С., Климов Ю.В., Альтшулер Б.Ю., Губкин А.В. Тромбофилия и беременность. Клиническая онкогематология. 2017; 10(3): 409-22.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies