Modern methods of fertility preservation in female patients with reproductive system cancers


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Abstract

The review discusses methods for preserving genetic material in reproductive-aged patients with reproductive system neoplasms. It gives the data of foreign and Russian articles found in PubMed on the current topic. Reproductive system cancers are mainly treated by radical removal of reproductive organs. In this connection, the direction of oncofertility has become an integral part in the patients’ life after surgical and chemo and radiation treatments. The paper describes the effect of gonadotoxic treatment on ovarian function. The preservation of genetic material and the realization of a woman’s reproductive potential is an important aspect that affects the future quality of life. Innovative fertility preservation technologies allow the optimal management strategies to be determined for patients suffering from various cancer types. The review considers standard methods for preserving genetic material in cancer patients. It discusses current fertility preservation programs: in vitro maturation (IVM) of oocytes obtained from ovarian tissue, as well as ovarian tissue cryopreservation, and a combination of these methods. Conclusion. This review of the scientific literature demonstrates the important role of innovative fertility preservation methods (IVM, ovarian tissue cryopreservation) for patients with reproductive system cancers.

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About the authors

Ekaterina S. Bunyaeva

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: es_bunyaeva@mail.ru
PhD student at 1st Gynecology Department

Anastasia O. Kirillova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_kozyreva@oparina4.ru
PhD (Bio Sci), Senior Researcher at the 1st Gynecology Department

Grigory N. Khabas

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: khabas@list.ru
PhD, Chief of the Department of Innovative Oncology and Gynecology

Aidar N. Abubakirov

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_abubakirov@oparina4.ru
PhD, Chief of the 1st Gynecology Department

Nona G. Mishieva

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: nondoc555@mail.ru
PhD, Senior Researcher of the 1st Gynecology Department

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