The significance of lipidomic changes in ovarian neoplasms


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Abstract

A number of lipids have tumor-initiating activity and this is the reason why the term "oncolipid" has been introduced. The content of various oncolipids in the tumor microenvironment reflects their ability to initiate and maintain the stages of carcinogenesis. This review analyzes the data available in the 2016-2020 literature from the databases Scopus, Medline, Cochrane, PubMed, eLibrary (with access to a full-text resource), and Web of Science, which is devoted to the study of lipid metabolic processes in ovarian malignancies. It analyzes the current promising studies of oncolipidomics, presents the possibilities of detecting early stage disease, summarizes data on the involvement of lipids in the process of initiation and progression of serous ovarian cancer and on the diagnostic and prognostic value of detecting lipidomic changes by mass spectrometry, and traces the relationship of these changes to the aggressiveness of the disease and its sensitivity to chemotherapy. The changes in the lipid composition are the pathogenetic result of accelerated cell division, impaired activation of the inositol-3-phosphate pathway, and intensive fatty acid ß-oxidation. The largest number of studies is devoted to the classes of lipids, such as phosphatidylcholines and sphingomyelins. The activity of lysophosphatidic acid is one of the key factors in the process of tumor progression in ovarian cancer. Conclusion. Interpretation of the study results is possible due to the unified lipid classification available in the Lipid Maps and Human Metabolome Database.

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About the authors

Mariia V. Iurova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation; I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University)

Email: m_yurova@oparina4.ru
MD, specialist, Department of System Biology in Reproduction, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia; post-graduate student, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Department of Obstetrics, Gynecology, Perinatology and Reproductive Health; the Faculty of Higher Professional Training Moscow, Russia

Stanislav V. Pavlovich

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation; I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University)

Email: s_pavlovich@oparina4.ru
obstetrician-gynecologist, MD, PhD, Scientific secretary Moscow, Russia

Grigory N. Khabas

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: g_khabas@oparina4.ru
surgeon, oncologist, obstetrician-gynecologist, MD, PhD, Head of the Department of Innovative Oncology and Gynecology Moscow, Russia

Vitaliy V. Chagovets

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: vvchagovets@gmail.com
PhD, Senior Researcher of the Laboratory of Proteomics and Metabolomics in Human Reproduction, Department of Systems Biology Moscow, Russia

Vladimir E. Frankevich

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: v_frankevich@oparina4.ru
PhD, Head of the Department of System Biology in Reproduction Moscow, Russia

Lev A. Ashrafyan

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: levaa2004@yahoo.com
Academician of the Russian Academy of Sciences, MD, Professor, Head of the Institute of Oncogynecology and Mammology Moscow, Russia

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