Antenatal factors associated with factors associated with brain-derived neurotrophic factor and insulin-like growth factor-1 levels in premature infants


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Abstract

Aim. The study was aimed at determining antenatal factors associated with brain-derived neurothophic factor and insulin-like growth factor-1 levels in premature infants. Materials and methods. The prospective study included 62 mother-infant pairs. The women and newborns were divided into two groups depending on gestational age at birth: group I included 21 mother-infant pairs with spontaneous preterm birth (PTB), the average gestational age for births was 33.3+1.93 weeks; group II included 41 mother-infant pairs with term birth (TB) at 39,4+1,04 weeks. Enzyme immunoassay (EIA) was performed for quantitative detection of brain-derived neurotrophic factor and insulin-like growth factor-1 levels in blood plasma of newborns. Results. BDNF level was high in the term birth group (р<0.0001), while IGF-1 level was low (р=0.0038). In the preterm birth group, the median BDNF value in women who had treatment for prevention of respiratory distress syndrome (RDS) in newborns was 488.5[70.9; 2295]pg/ml, and 326.5[133.4; 2730]pg/ml in women who did not receive RDS profilaxis, р=0,9644. In the preterm birth group, the median value of IGF-1 was 45.3 [28.3; 58.1] ng/ml in women who received RDS profilaxis, and 90.9 [57.7; 252.3] ng/ml in women who did not receive RDS profilaxis, р=0.0197. Conclusion. The specific features of the course of pregnancy affect BDNF and IGF-1 levels in blood plasma of premature infants, including antenatal prophylaxis of RDS and antibiotic therapy.

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About the authors

Ksenia A. Gorina

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: k_gorina@oparina4.ru
Junior researcher at the Department of Pregnancy Pathology Moscow, Russia

Zulfiya S. Khodzhaeva

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: zkhodjaeva@mail.ru
Dr. Med. Sci, Professor, Deputy Director for Research of Obstetrics Institute Moscow, Russia

Valentina V. Vtorushina

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: vtorushina@inboxru
PhD, clinical laboratory diagnostics doctor of the Laboratory of Clinical Immunology Moscow, Russia

Liubov V. Krechetova

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: l_krechetova@oparina4ru
Dr. Med. Sci., Head of the Laboratory of Clinical Immunology Moscow, Russia

Oleg V. Ionov

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: o_ionov@oparina4.ru
MD, PhD, Head of the of the NICU named after professor Antonov A.G. of the Institute of Neonatology and Pediatrics Moscow, Russia

Anna A. Lenyushkina

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: a-lenushkina@yandex.ru
PhD, Head of the Neonatal Intensive Care Unit No. 2 of the Institute of Neonatology and Pediatrics Moscow, Russia

Leyla A. Timofeeva

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: lematimofeeva@mail.ru
PhD, Head of the Department of Newborns No. 1 Moscow, Russia

Mzia I. Makieva

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: m_makieva@oparina4.ru
Dr. Med. Sci., Professor, Deputy Director for Research Moscow, Russia

Dmitriy N. Degtyarev

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: d_degtiarev@oparina4.ru
Moscow, Russia

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