Specific features of molecular mechanisms of vaginal secretion in women with decline in sexual function in assisted reproductive technology programs
- Authors: Stenyaeva N.N.1, Krasnyi A.M.2, Khritinin D.F.3, Burduli A.G.1, Sadekova A.A.1, Kostava M.N.1, Kalinina E.A.1
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Affiliations:
- Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
- Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
- I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
- Issue: No 7 (2021)
- Pages: 165-173
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/249440
- DOI: https://doi.org/10.18565/aig.2021.7.165-173
- ID: 249440
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Abstract
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About the authors
Natalia N. Stenyaeva
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: nataliasten@mail.ru
MD, PhD, Senior Researcher of the Department of Andrology and Urology
Alexey M. Krasnyi
Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: a_krasnyi@oparina4.ru
PhD, Head of the Laboratory of Cytology
Dmitry F. Khritinin
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)Corresponding Member of the RAS, Dr. Med. Sci., Professor of the Department of Psychiatry and Narcology, Faculty of General Medicine
Anna G. Burduli
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: burdulianna@gmail.com
MD, PhD, Senior Researcher of IVF Department
Alsu A. Sadekova
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: sialsad@gmail.com
PhD (Bio), researcher of the Cytology Laboratory
Marina N. Kostava
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of RussiaPhD, obstetrician-gynecologist, doctor of the highest category
Elena A. Kalinina
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: e_kalinina@oparina4.ru
Dr. Med. Sci., Professor, Head of the Department of Assisted Technologies for the Treatment of Infertility, Scientific Secretary of the Dissertation Council
References
- Wischmann T., Schilling K., Toth B., Rosner S., Strowitzki T., Wohlfarth K., Kentenich H. Sexuality, self-esteem and partnership quality in infertile women and men. Geburtshilfe Frauenheilkd. 2014; 74(8): 759-63. https://dx.doi.org/10.1055/s-0034-1368461.
- Galhardo A., Moura-Ramos M., Cunha M., Pinto-Gouveia J. Infertility is a trap: how defeat and trapping are affected by depressive symptoms. Hum. Reprod. 2016; 31(2): 419-26. https://dx.doi.org/10.1093/humrep/dev311.
- Peterson B.D., Sejbaek C.S., Pirritano M., Schmidt L. Are there severe depressive symptoms associated with infertility of distress in individuals about related and their partners? Hum. Reprod. 2014; 29(1): 76-82. https://dx.doi.org/10.1093/humrep/det412.
- Cizmeli C., Lobel M., Franasiak J., Pastore L.M. Levels and associations among self-esteem, fertility distress, coping, and reaction to potentially being a genetic carrier in women with diminished ovarian reserve. Fertil. Steril. 2013; 99(7): 2037-44. https://dx.doi.org/10.1016/j.fertnstert.2013.02.033.
- Keramat A., Masoomi S.Z., Mousavi S.A., Poorolajal J., Shobeiri F., Hazavhei S.M. Quality of life and its related factors in infertile couples. J. Res. Health Sci. 2014; 14(1): 57-63.
- Васильченко Г.С., ред. Общая сексопатология. Руководство для врачей. М.: Медицина; 1977: 75-87, 168-75.
- Васильченко Г.С., ред. Общая сексопатология. Руководство для врачей. 2-е изд. М.: Медицина; 2005. 510с.
- Kazakov D.V., Stewart C.J., Kacerovska D., Leake R., Kreuzberg B., Chudacek Z., Hora M., Michal M. Prostatic-type tissue in the lower female genital tract: a morphologic spectrum, including vaginal tubulosquamous polyp, adenomyomatous hyperplasia of paraurethral Skene glands (female prostate), and ectopic lesion in the vulva. Am. J. Surg. Pathol. 2010; 34(7): 950-5. https://dx.doi.org/10.1097/PAS.0b013e3181e0f371.
- Koduri S., Goldhar A., Vonderhaar B. Activation of vascular endothelial growth factor (VEGF) by the ER-a variant, ERA3. Breast Cancer Res. Treat. 2006; 95(1): 37-43. https://dx.doi.org/10.1007/s10549-005-9028-4.
- Huang Y.T., Zhou J., Shi S., Xu H.Y., Qu F., Zhang D. et al. Identification of estrogen response element in aquaporin-3 gene that mediates estrogen-induced cell migration and invasion in estrogen receptor-positive breast cancer. Sci. Rep. 2015; 5: 12484. https://dx.doi.ois/10.1038/srep12484.
- Nephew K.P., Long X., Osborne E., Burke K.A., Ahluwalia A., Bigsby R.M. Effect of estradiol on estrogen receptor expression in rat uterine cell types. Biol. Reprod. 2000; 62(1): 168-77.
- Kim S.O., Oh K.J., Lee H.S., Ahn K., Kim S.W., Park K. Expression of aquaporin water channels in the vagina in premenopausal women. J. Sex. Med. 2011; 8(7): 1925-30. https://dx.doi.org/10.1111/j.1743-6109.2011.02284.x.
- Lee H.S., Kim S.O., Ahn K., Park K. All-trans retinoic acid increases aquaporin 3 expression in human vaginal epithelial cells. Sex. Med. 2016; 4(4): e249-54. https://dx.doi.org/10.1016/j.esxm.2016.07.001.
- Dvorak H.F., Brown L.F., Detmar M., Dvorak A.M. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am. J. Pathol. 1995; 146(5): 1029-39.
- Sondell M., Sundler F., Kanje M. Vascular endothelial growth factor is a neurotrophic factor which stimulates axonal outgrowth through the flk-1 receptor. Eur. J. Neurosci. 2000; 12(12): 4243-54. https://dx.doi.org/10.1046/j.0953-816X.2000.01326.x.
- Storkebaum E., Lambrechts D., Carmeliet P. VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection. Bioessays. 2004; 26(9): 943-54. https://dx.doi.org/10.1002/bies.20092.
- Zhang Y., Furumura M., Morita E. Distinct signaling pathways confer different vascular responses to VEGF 121 and VEGF 165. Growth Factors. 2008; 26(3): 125-31. https://dx.doi.org/10.1080/08977190802105909.
- Reed B.G., Carr B.R. The normal menstrual cycle and the control of ovulation. [Updated 2018 Aug 5]. In: Feingold K.R., Anawalt B., Boyce A., Chrousos G., de Herder W.W., Dhatariya K. et al., eds. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000. Available at: https://www.ncbi.nlm.nih.gov/books/NBK279054/
- Ullah K., Rahman T.U., Pan H.T., Guo M.X., Dong X.Y., Liu J. et al. Serum estradiol levels in controlled ovarian stimulation directly affect the endometrium. J. Mol. Endocrinol. 2017; 59(2): 105-19. https://dx.doi.org/10.1530/ JME-17-0036.
- Carosso A., Revelli A., Gennarelli G., Canosa S., Cosma S., Borella F. et al. Controlled ovarian stimulation and progesterone supplementation affect vaginal and endometrial microbiota in IVF cycles: a pilot study. J. Assist. Reprod. Genet. 2020; 37(9): 2315-26. https://dx.doi.org/10.1007/s10815-020-01878-4.
- Rosen R., Brown C., Heiman J., Leiblum S., Meston C., Shabsigh R. et al. The Female Sexual Function Index (FSFI): a multidimensional selfreport instrument for the assessment of female sexual function. J. Sex Marital Ther. 2000; 26(2): 191-208. https://dx.doi.org/10.1080/009262300278597.
- Tanha F.D., Mohseni M., Ghajarzadeh M. Sexual function in women with primary and secondary infertility in comparison with controls. Int. J. Impot. Res. 2014; 26(4): 132-4. https://dx.doi.org/10.1038/ijir.2013.51.
- Keskin U., Coksuer H., Gungor S., Ercan C.M., Karasahin K.E., Baser I. Differences in prevalence of sexual dysfunction between primary and secondary infertile women. Fertil. Steril. 2011; 96(5): 1213-7. https://dx.doi.org/10.1016/j.fertnstert.2011.08.007.
- Azadzoi K.M., Siroky M.B. Neurologic factors in female sexual function and dysfunction. Korean J. Urol. 2010; 51(7): 443-9. https://dx.doi.org/10.4111/ kju.2010.51.7.443.
- Woodard T.L., Diamond M.P. Physiologic measures of sexual function in women: a review. Fertil. Steril. 2009; 92(1): 19-34. https://dx.doi.org/10.1016/ j.fertnstert.2008.04.041.
- Li S., Herrera G.G., Tam K.K., Lizarraga J.S., Beedle M.T., Winuthayanon W. Estrogen action in the epithelial cells of the mouse vagina regulates neutrophil infiltration and vaginal tissue integrity. Sci. Rep. 2018; 8(1): 11247. https://dx.doi.org/10.1038/s41598-018-29423-5.
- Исламов Р.Р., Валиуллин В.В., Мурашов А.К. Механизмы нейропро-текторного действия эстрогенов, связанные с экспрессией фактора роста эндотелия сосудов. Биологический бюллетень РАН. 2007; 34: 110-9. [Islamov R.R., Valiullin V.V., Murashov A.K. Mechanisms of the neuroprotective action of estrogens associated with the expression of vascular endothelial growth factor. Biology Bulletin. 2007; 34: 110-9]. https://dx.doi.org/10.1134/S1062359007020021.
- Apte R.S., Chen D.S., Ferrara N. VEGF in signaling and disease: beyond discovery and development. Cell. 2019; 176(6): 1248-64.
- Giacca M., Zacchigna S. VEGF gene therapy: therapeutic angiogenesis in the clinic and beyond. Gene Ther. 2012; 19: 622-9. https://dx.doi.org/10.1038/gt.2012.17.
- Theis V., Theiss C. VEGF - A stimulus for neuronal development and regeneration in the CNS and PNS. Curr. Protein Pept. Sci. 2018; 19(6): 589-97. https://dx.doi.org/10.2174/1389203719666180104113937.
- Abir-Awan M., Kitchen P., Salman M.M., Conner M.T., Conner A.C., Bill R.M. Inhibitors of mammalian aquaporin water channels. Int. J. Mol. Sci. 2019; 20(7): 1589. https://dx.doi.org/10.3390/ijms20071589.
- Fiorentini D., Zambonin L., Dalla Sega F.V., Hrelia S. Polyphenols as modulators of aquaporin family in health and disease. Oxid. Med. Cell. Longev. 2015; 2015: 196914. https://dx.doi.org/10.1155/2015/196914.
- Ribeiro J.C., Alves M.G., Yeste M., Cho Y.S., Calamita G., Oliveira P.F. Aquaporins and (in)fertility: More than just water transport. Biochim. Biophys. Acta Mol. Basis Dis. 2020; 1867(3): 166039. https://dx.doi.org/10.1016/j.bbadis.2020.166039.
- Hara-Chikuma M., Satooka H., Watanabe S., Honda T., Miyachi Y., Watanabe T., Verkman A.S. Aquaporin-3-mediated hydrogen peroxide transport is required for NF-kB signalling in keratinocytes and development of psoriasis. Nat. Commun. 2015; 6: 7454. https://dx.doi.org/10.1038/ncomms8454.
- Zhu N., Feng X., He C., Gao H., Yang L., Ma Q. et al. Defective macrophage function in aquaporin-3 deficiency. FASEB J. 2011; 25(12): 4233-9. https://dx.doi.org/10.1096/fj.11-182808.
- Hara-Chikuma M., Chikuma S., Sugiyama Y., Kabashima K., Verkman A.S., Inoue S., Miyachi Y. Chemokine-dependent T. cell migration requires aquaporin-3-mediated hydrogen peroxide uptake. J. Exp. Med. 2012; 209(10): 1743-52. https://dx.doi.org/10.1084/jem.20112398.