The state of adolescent girls' reproductive health

Objective. The study aimed to characterize the normative AMH levels amongst adolescent girls in Armenia, assess reproductive health, and take preventive measures for infertility. Materials and methods. The study included 700 10-18-year-old adolescent girls randomly selected from different regions of Armenia, including Yerevan. Clinical evaluation included serum levels of AMH, FSH, LH, TSH, anti-TPO, as well as thyroid gland and pelvic ultrasound examination. Results. The individual AMH level in 10-15-year-old adolescent girls ranged from 2.0 to 4.0 ng/ml and among 16-18-year-old adolescent girls from 1.5-4.0 ng/ml. The normal ovarian reserve has the following characteristics: AMH level not less than 2.0 mg/ml, FSH level not more than 10 m U/ml, AFC at least 5 in each ovary, and ovarian volume, not less than 5cm3. A total of 469 (67%) adolescents had a normal AMH level and normal ovarian reserve. 231 (33%) adolescent girls were at high risk for diminished ovarian reserve, menstrual disorders, infertility, and reproductive losses. Conclusion. The study established the normative values for serum AMH and evaluated the normal ovarian reserve of Armenian adolescent girls. Knowledge of low ovarian reserve and its prognostic significance allows identifying risk groups of adolescent girls at an early stage. This enables the determination of reproductive behavior and prevention of reproductive losses and infertility in the reproductive age.

Adolescent girls, Anti-Mullerian hormone (AMH), reproductive health, Antral follicle count (AFC), Ovarian reserve (OR), Follicle stimulating hormone (FSH), Luteinizing hormone (LH)