Changes in the concentrations of biomarkers of inflammation, endothelial dysfunction, and oxidative stress in menstrual discharge during bacteriophage and laser therapy for chronic nonspecific endometrial inflammation


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Abstract

The paper considers the treatment of chronic nonspecific endometritis and related reproductive dysfunctions. Objective. To study the effect of the combined use of a bacteriophage and infrared laser treatment on a number of menstrual discharge parameters in patients with a history of chronic endometritis and infertility. Subjects and methods. A total of333patients were examined; 88 patients with a history of chronic endometritis and infertility were treated. Fifty-eight patients in a study group received bacteriophage and laser therapy according to the proposed original procedure. Thirty patients in a control group had conventional anti-inflammatory therapy. Before and 2.5-3 months after treatment, tests for interleukin-6, glutathione-peroxidase-1, and soluble E-selectin were carried out to estimate a number of menstrual discharge biomarkers reflecting different pathogenetic aspects of endometrial dysfunction during the inflammatory process. Results. The study group patients receiving combined bacteriophage and laser therapy showed a substantial improvement in menstrual blood parameters, which was evidence of an effective local immune response of the uterine mucosa, by leveling inflammation, oxidative stress, and endothelial dysfunction. Such clear positive changes could not be achieved in patients receiving conventional treatment. Conclusion. The combination of bacteriophage therapy and low-intensity infrared laser radiation sessions according to the proposed procedure is an etiopathogenetically justified and effective way of treating chronic nonspecific endometrial inflammation in infertile women.

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About the authors

Tatyana M. Motovilova

Volga Regional Research Medical University, Ministry of Health of Russia

Email: tmshka@mail.ru;tatyana.m.motovilova@gmail.com
Ph.D., Associate Professor at the Department of Obstetrics and Gynecology

Tatyana S. Kachalina

Volga Regional Research Medical University, Ministry of Health of Russia

Email: yander24@bk.ru
Dr. Med. Sci., Professor of the Department of Obstetrics and Gynecology

Lyudmila V. Borovkova

Volga Regional Research Medical University, Ministry of Health of Russia

Email: borovkovalv@yandex.ru
Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology

Gennady O. Grechkanev

Volga Regional Research Medical University, Ministry of Health of Russia

Email: ggrechkanev@mail.ru
Dr. Med. Sci., Professor of the Department of Obstetrics and Gynecology

Olga S. Zinovyeva

Volga Regional Research Medical University, Ministry of Health of Russia

Email: zamashkina87@mail.ru
Assistant of the Department of Obstetrics and Gynecology

Irina V. Ponomareva

"Sadko" Modern Technology Clinic

Email: ponomareva_irina_70@mail.ru
obstetrician-gynecologist, chief physician of the network of clinics „Sadko”

Irina V. Martyantseva

"Sadko" Modern Technology Clinic

Email: martyantseva1989@mail.ru
Head of the Laboratory Diagnostics Service of the network of clinics „Sadko”

Yulia A. Gagaeva

Volga Regional Research Medical University, Ministry of Health of Russia

Email: ya.gagaeva-julia@yandex.ru
clinical intern at the Department of Obstetrics and Gynecology

Ekaterina V. Banykina

Volga Regional Research Medical University, Ministry of Health of Russia

Email: ekaterinabanykina@gmail.com
6th year student of the General Medicine Faculty

Shakhzoda B. Razikova

Volga Regional Research Medical University, Ministry of Health of Russia

6th year student of the General Medicine Faculty

Olga V. Anikeeva

Volga Regional Research Medical University, Ministry of Health of Russia

4th year student of the General Medicine Faculty

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