Gut and genital microbiota in endometriosis


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Abstract

Endometriosis is a hormone-dependent disease associated with the development of chronic inflammation. The prevalence of this disease does not tend to decrease. The absence of a unif ied generally accepted theory on the origin of endometriosis is the basis for continuing investigations aimed at searching for possible mechanisms for the development of the disease in order to improve the principles of diagnosis and therapy of this pathological process. One of the theories of endometriosis is the hypothesis of bacterial infection, in which the bacterial endotoxin lipopolysaccharide is supposed to be a triggering factor for the onset and progression of endometriosis. Current data indicate that changes in the composition of gut microbiota and/or different stages of the female reproductive tract can be used prognostically as a tool for diagnosing the disease, whereas a number of microorganisms can be marker for assessing its form and prevalence. This review considers the present-day ideas on the relationship between the gut and genital microbiotas and endometriosis, on possible mechanisms and diagnostic approaches to this pathological condition. Conclusion: To study the composition of the microbiota seems to be a fairly new and very promising area from both scientific and practical point of view.

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About the authors

Galina E. Chernukha

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: c-galina1@yandex.ru
Dr. Med. Sci., Professor, Chief Researcher, obstetrician-gynecologist at the Department of Gynecological Endocrinology

Veronika A. Pronina

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: ver22595@yandex.ru
obstetrician-gynecologist, PhD student

Tatiana V. Priputnevich

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: priput1@gmail.com
Dr. Med. Sci., Associate Professor, Director of the Institute of microbiology, antimicrobial therapy and epidemiology

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