The role of lipidomic studies in human reproduction and in the outcomes of infertility treatment programs using assisted reproductive technologies


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Abstract

Lipids and lipophilic trace elements are of increasing interest as potential non-invasive predictive molecules for in vitro fertilization outcomes. Their antioxidant and/or pro-inflammatory activities have an impact on female and male reproductive functions. Since the causes of fertility disorders may be related to metabolic imbalance, metabolomics can be applied to reproductive medicine to identify and quantify low-molecular-weight metabolites in follicular fluid and in the germ cells of couples undergoing assisted reproductive technologies. Studying the effect of lipids on the outcomes of assisted reproductive technologies in order to correct lipid metabolism disorders will help to improve live birth rates. Data from the Russian and foreign articles found in PubMed (http://pubmed. ncbi.nim.nih.gov) and published over the past 5 years were systematically analyzed. The paper presents data from studies investigating the lipidome of follicular fluid, spermatozoa and seminal plasma, blood plasma from couples and the possible prospects for studies in assisted reproductive technology programs. Conclusion: Despite the extent of current investigations, the question of the combined mutual influence of the lipid profile of female and male gametes and blood of patients on the parameters of oogenesis, spermatogenesis, and embryogenesis, and, accordingly, on the outcomes of assisted reproductive technology programs, remains open. Further investigations are needed to study lipidome in order to predict the outcomes of treatment with assisted reproductive technologies and to develop possible interventions to correct the lipidome composition.

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About the authors

Luliia A. Fortygina

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: yu_fortygina@oparina4.ru
postgraduate student

Natalya P. Makarova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: np_makarova@oparina4.ru
Dr. Bio. Sci., Leading Researcher, Department of IVF named after Prof. BV. Leonov

Oksana S. Nepsha

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: o_nepsha@oparina4.ru
PhD (Bio), Researcher, Department of IVF named after Prof. B.V. Leonov

Nataliya N. Lobanova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: n_lobanova@oparina4.ru
Researcher, Department of IVF named after Prof. BV. Leonov

Elena A. Kalinina

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_kalinina@oparina4.ru
Dr. Med. Sci., Professor, Head of the IVF department named after Prof. BV. Leonov

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