EFFICIENCY OF ASSISTED REPRODUCTIVE TECHNOLOGY IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME WHO UNDERGO PREIMPLANTATION GENETIC TESTING FOR ANEUPLOIDY


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Abstract

Objective: To compare the efficiency of assisted reproductive technology (ART) with and without preimplantation genetic testing for aneuploidy (PGT-A) in women with polycystic ovarian syndrome (PCOS). Materials and methods: The study included 80 infertile women with PCOS who underwent assisted reproductive technology (ART) with gonadotropin-releasing hormone (GnRH) antagonists. The patients were divided into Group 1 (n=40) including women who underwent IVF/ICSI/PGT-A and Group 2 (n=40) including women who underwent IVF or IVF/ICSI without PGT-A. In all ovarian stimulation programs, 0.2 mg of GnRH antagonist was used as a trigger instead of human chorionic gonadotropin; a cycle segmentation technique was used. All patients underwentfrozen-thawed embryo transfer. Results: The PGT-A group had a 10% (4/40) higher rate of pregnancies that ended in childbirth [14/40 (35%)] than the group without PGT-A [10/40 (25%)], RR 1.40 (95% CI 0.71-2.77), p=0.46; differences between groups were not statistically significant. The differences in the biochemical pregnancy rate [0/40 in the PGT-A group and 4/40 (10%) in the group without PGT-A, p=0.34] and the miscarriage rate [3/40 (7.5%) in the group with PGT-A and 8/40 (20%) in the group without PGT-A (RR 0.38 (95% CI 0.08-1.31), p=0.10] were also not statistically different. Still, there was a tendency for these complications to decrease in patients who underwent PGT-A. The pregnancy rates were not statistically different between the two study groups: 18/40 (45%) in the group with PGT-A and 22/40 (55%) in the group without PGT-A (RR 0.82 (95% CI 0.53-1.27), p=0.37). Conclusion: PGT-A in PCOS patients demonstrates its clinical value, but further studies are needed in a larger sample of patients, investigating embryological stage factors and taking into account both the success rates of pregnancy after frozen-thawed embryo transfer and the effectiveness of these programs in this category of patients, and obstetric and perinatal outcomes.

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About the authors

Nina D. MIKHAILOVA

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: mihailnina@mail.ru
Ph.D. Student at the 1st Gynecology Department Moscow, Russia

Artem A. AKSENENKO

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: a_axenenko@oparina4.ru
Gynecologist at the 1st Gynecology Department Moscow, Russia

Muminat Kh. IBRAGIMOVA

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: m_ibragimova@oparina4.ru
Ph.D., Gynecologist at the 1st Gynecology Department, Academician Moscow, Russia

Alexey N. EKIMOV

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: a_ekimov@oparina4.ru
Laboratory geneticist at the Laboratory of Molecular Genetics Moscow, Russia

Alla A. GAVISOVA

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: gavialla@yandexru
Ph.D., Senior Researcher at the 1st Gynecology Department, National Medical Research Center for Obstetrics Moscow, Russia

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