Achieving pregnancy at a late reproductive age in a patient with a history of multiple failed in vitro fertilization attempts

Background. As a woman gets older, her ovarian reserve is diminished, her egg quality is worse, the number of concomitant somatic diseases and reproductive tract pathologies increases. This causes a substantial reduction in her likelihood of conception not only spontaneously, but also with the use of assisted reproductive technology (ART). On this basis, reproductologists’ efforts are aimed at searching for new methods to overcome infertility in older reproductive-aged patients. Case report. This paper reviews a clinical case of ART singlet pregnancy and birth of a baby to an older married couple (a 42-year-old woman and her 54-year-old husband) after 13 failed IVF attempts. Implementation of the 14th IVF program using the female patient’s own eggs and her husband’s sperm after auxiliary zygote activation with calcium ionophore A23187 and co-culture of embryos on the feeder layer could obtain two embryos, the transfer of which led to the onset of a singlet pregnancy and birth of a baby. At 39 weeks’ gestation, the patient delivered spontaneously a healthy girl weighing 3190 g. Conclusion. An individual approach to choosing methodological solutions (by an embryologist) and therapy (by a reproductlogist and an andrologist) for a specific infertile couple contributes to the achievement of pregnancy and childbirth in older couples with multiple failed IVF attempts

infertility, late reproductive age, ovarian reserve depletion, multiple failed IVF attempts, pregnancy, clinical case