CD163 positive alternatively activated monocytes as a marker of early miscarriage
- Authors: Farzalieva A.V.1, Sotnikova N.Y.1, Borzova N.Y.1
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Affiliations:
- V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia
- Issue: No 8 (2022)
- Pages: 71-75
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/249525
- DOI: https://doi.org/10.18565/aig.2022.8.71-75
- ID: 249525
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Abstract
Objective: To develop a new method for predicting spontaneous miscarriage in women with threatened miscarriage in early pregnancy by detection of alternatively activated monocytes expressing the scavenger receptor CD163 in peripheral venous blood. Materials and methods: The study included 71 women between 5 and 12 weeks of gestation. Of these, 54 women gave birth at full term (Group 1) and 17 women had early and late spontaneous miscarriages (Group 2). The relative abundance of CD14+CD16++ monocytes expressing the scavenger receptor CD163 was determined using a FACScanto II flow cytometer (Becton Dickinson, USA). Peripheral venous blood served as the material for the study. Results: There was no significant difference between the two groups in the content of classically activated and intermediately activated monocytes expressing the scavenger receptor CD163. However, the content of alternatively activated monocytes expressing the CD163 scavenger receptor in women with spontaneous miscarriage was statistically different from that of women who gave birth at full-term. Conclusion: The content of alternatively activated monocytes expressing the CD163 scavenger receptor in peripheral blood can be used as a predictor of spontaneous miscarriage in women with threatened miscarriage in early pregnancy.
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About the authors
Aiten V. Farzalieva
V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia
Email: farzaliyeva_a_v@man.ru
Postgraduate Student at the Department of Obstetrics and Gynecology, Neonatology, Anesthesiology and Resuscitation
Natalia Yu. Sotnikova
V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia
Email: niimid.immune@mail.ru
Dr. Med. Sci., Professor, Head of the Laboratory of Clinical Immunology
Nadezda Yu. Borzova
V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia
Email: borzova_n@mail.ru
Dr. Med. Sci., Professor, Chief Researcher at the Department of Obstetrics and Gynecology, Neonatology, Anesthesiology and Resuscitation
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