Uterine sarcoma and pregnancy: modern view on the problem

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Abstract

The scientific review considers a gynecological disease, such as uterine sarcoma. The paper presents the main definitions of the gynecological disease, provides statistical data on the prevalence of this disease, describes its current classifications, and touches upon the etiological and pathogenetic aspects of uterine sarcoma. It reviews the current foreign and Russian sources of literature data on the incidence of uterine sarcoma during pregnancy and analyzes the outcomes of pregnancies. The authors also discuss the general principles of surgical treatment for this type of cancer, give an account of the possible volumes of surgical intervention, and highlight the expediency and principles of radiation therapy and adjuvant chemotherapy. They detail clinical outcomes and survival rates in women after surgical intervention of varying complexity and volume. Much attention is paid to the incidence of uterine sarcoma in women of childbearing age who are interested in maintaining their reproductive function in the future. The paper describes treatment options for uterine sarcoma (presents clinical cases), by preserving further female reproductive function, namely organ-sparing operations. Conclusion: Organ-sparing operations in women of childbearing age with detected uterine sarcoma are an experimental procedure. However, the data on survival rates are more encouraging in patients with lowand moderate-grade endometrial stromal sarcoma (LMGESS) after organ-sparing surgery. From this it is inferred that organ-sparing surgery can be proposed and performed in women who are interested in maintaining their reproductive function.

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About the authors

Vitaly B. Tskhay

Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia

Email: tchai@yandex.ru
Dr. Med. Sci., Professor, Head of the Department of Perinatology, Obstetrics and Gynecology of the Medical Faculty

Alexander I. Pashov

Immanuel Kant Baltic Federal University

Email: pachov@mail.ru
Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology of the Medical Institute

Lev A. Ashrafyan

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: levaa2004@yahoo.com
Academician of the RAS, Dr. Med. Sci., Professor, Deputy Director

Valeria V. Rachkovskaya

Immanuel Kant Baltic Federal University

Email: losevavaleria2l04@mail.ru
postgraduate student of the Department of Obstetrics and Gynecology of the Medical Institute

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