Feasibility of preimplantation genetic testing for aneuploidy in patients undergoing in vitro fertilization after conservative treatment of atypical hyperplasia and early endometrial cancer

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Abstract

Relevance: Atypical endometrial hyperplasia (AEH) and early endometrial cancer (EC) are frequently detected in female patients before the realization of their reproductive potential. Patients of older reproductive age with AEH and early EC have an increased risk of chromosomal pathology in offspring. Objective: To investigate the feasibility of preimplantation genetic testing for aneuploidy (PGT-A) of embryos in patients with a history of AEH and early EC undergoing IVF. Materials and methods: Fifty patients aged 25- 43years (median 35 years) who underwent IVF after conservative hormonal treatment for AEH and early EC constituted the study group. The control group included 40 patients with tubal-peritoneal and mild male factor infertility. We studied the pregnancy rate (PR) in patients of different age groups and the association between pregnancy rate and PGT-A during IVF. Results: Euploid blastocysts were obtained from 32% (32/100) of patients in the study group, of whom 74% (17/23) were aged <35 and 19% (15/77) >35 years. The rate of euploid embryos in the control group was comparable. The PR among all the patients in the study group was 32% (19/60); among them it was 38% (12/32) and 25% (7/28) in women <35 and >35 years, respectively. In the control group, PR was 41% (22/54) among all patients, including 46% (13/28) in patients of young reproductive age and 35% (9/26) in women >35 years. There was a correlation between PGT-A and PR. Among all patients in the study group who did and did not undergo PGT-A, PR was 47% (7/15) and 27% (12/45), respectively. In the control group, PR was 47% (9/19) among all patients who underwent PGT-A and 34% (12/35) among patients who refused PGT-A. Conclusion: The PGT-A of embryos during IVF can exclude chromosomal abnormalities in the retrieved embryos and increase PR by transferring an euploid embryo into the uterine cavity.

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About the authors

Ksenia V. Krasnopolskaya

Moscow Regional Research Institute of Obstetrics and Gynecology; Reproductive Health Clinic «PRIOR CLINIC»

Email: ksu0207@mail.ru
Dr. Med. Sci., Professor, Corr. Member of the RAS; Head of the Department of High Reproductive Technologies, Obstetrician-Gynecologist

Olga V. Novikova

Reproductive Health Clinic «PRIOR CLINIC»; M.F. Vladimirsky Moscow Regional Clinical Research Institute

Email: onov@bk.ru
Dr. Med. Sci., Professor, Obstetrician-Gynecologist, Oncological Gynecologist; Department of Obstetrics and Gynecology

Kamila M. Isakova

Moscow Regional Research Institute of Obstetrics and Gynecology

Email: isa-kama@yandex.ru
PhD, Obstetrician-Gynecologist, Researcher

Lidiya V. Shostenko

Moscow Regional Research Institute of Obstetrics and Gynecology

Email: lidsonnn@gmail.com
Obstetrician-Gynecologist, Postgraduate Student at the Department of Reproduction

Daria I. Rau

Moscow Regional Research Institute of Obstetrics and Gynecology

Email: dariarau23@gmail.com
Obstetrician-Gynecologist, Postgraduate Student at the Department of Reproduction

Anna V. Shishkina

Moscow Regional Research Institute of Obstetrics and Gynecology

Email: anya.shostenko@yahoo.com
Obstetrician-Gynecologist, Postgraduate Student at the Department of Reproduction

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