Correction of iron deficiency states in reproductive-aged patients with chronic abnormal uterine bleeding

Objective: To evaluate the effectiveness of correcting iron deficiency states (IDS) in chronic abnormal uterine bleeding (AUB) in reproductive-aged patients. Materials and methods: The investigation enrolled 155patients with chronic AUB. Group 1 included 53patients with latent iron deficiency (LID); Group 2 consisted of 58 women with mild iron deficiency anemia (IDA); Group 3 comprised 44 patients with moderate IDA. The investigation methods included the determination of the level of serum iron (SI), total serum iron-binding capacity (TSIC), ferritin, and complete blood cell count parameters (hemoglobin, red blood cell count, mean corpuscular volume (MCV), cellular hemoglobin content (CHC) in serum). IDS was treated with a combination agent containing ferrous fumarate and folic acid (Ferretab comp.) for 12 and 24 weeks. Therapy outcome assessments were based on determination of hemoglobin and ferritin levels and on clinical evaluation of complaints potentially associated with iron deficiency. Results: It was established that effective correction of IDS in chronic AUB in reproductive-aged patients could be achieved by routine administration of the drug containing ferrous fumarate and folic acid (Ferretab comp.), by taking into account its efficacy and good tolerability, which determined adherence to therapy. After 12 weeks of taking this drug, there was a rise in hemoglobin and ferritin levels in Groups 1 and 2 and a statistically significant increase in hemoglobin levels in Group 3 (p=0.01). In addition, the common symptoms of anemia were recorded to be relieved in all the women included in the investigation. Conclusion: The combination drug Ferretab comp. is effective in restoring hemoglobin levels and iron stores in patients with IDS in chronic AUB. This combination drug has prescription benefits for IDS, since folic acid is an iron synergist for erythropoiesis and also due to the need to maintain optimal serum folate levels in reproductive-aged patients.

abnormal uterine bleeding, latent iron deficiency, iron deficiency anemia, oral iron agents