Serum 25-hydroxycalciferol levels in cholecalciferol prophylaxis during breastfeeding


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Abstract

The high prevalence of vitamin D deficiency in pregnant women and their newborns causes a number of complications that can be prevented. Nowadays, the use of prophylactic doses of vitamin D during pregnancy and lactation remains debatable and requires further study. Objective: To evaluate the saturation of the body of a woman and a newborn who was breastfed during vitamin D prophylaxis administered to mother. Materials and methods: The study included 110 women who recently gave birth and 100 newborns. Biological samples were collected for subsequent identification and retrospective assessment of serum 25-hydroxycalciferol levels. During breastfeeding, women of group I (n=54) received 400IUcholecalciferol, women of group II (n=56) received 1400 IU cholecalciferol. The children were exclusively breastfed and received 500 IU cholecalciferol additionally. The evaluation of 25(OH)D level was carried out using a chemiluminescent method after childbirth and after 6 months of breastfeeding. Results: Vitamin D deficiency and insufficiency were detected in 98/110 (89%) women who recently gave birth: deficiency was identified in 43/110 (39%) women, insufficiency was detected in 56/110 (50.9) women. Vitamin D deficiency was detected in 78/100 (78%) newborns and insufficiency was revealed in 22/100 (22%) newborns. Umbilical blood cord concentration of 25(OH)D corresponded to 67% of the content of 25(OH)D in the mother’s blood serum. After the use of vitamin D at a dose of 400 IU, deficiency and insufficiency persisted in 43/46 (93.5%) women; when vitamin D was administered at a dose of 1400 IU, deficiency and insufficiency were detected in 28/48 (58.3%) women. Deficiency and insuff iciency persisted in all children in the study regardless of the prophylactic dose of cholecalciferol taken by mother. Conclusion: Umbilical blood cord concentration of 25(OH)D is 1.5 times lower than one in the maternal serum. Prophylactic doses of cholecalciferol are insufficient in common vitamin D deficiency. It is recommended to determine 25(OH)D level when planning pregnancy and during lactation.

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About the authors

Tatiana V. Novikova

Almazov National Medical Research Center, Ministry of Health of the Russian Federation

Email: tanyanovikova.85@mail.ru
PhD, Assistant of the Department of Obstetrics and Gynecology, Institute of Medical Education

Irina E. Zazerskaya

Almazov National Medical Research Center, Ministry of Health of the Russian Federation

Email: zazera@mail.ru
Dr. Med. Sci., Head of the Department of Obstetrics and Gynecology

Lyubov V. Kuznetsova

Almazov National Medical Research Center, Ministry of Health of the Russian Federation

PhD, Head of Research Laboratory of Reproduction and Women's Health, Institute of Perinatology and Pediatrics

Margarita Yu. Vasilyeva

Almazov National Medical Research Center, Ministry of Health of the Russian Federation

PhD student of the Department of Obstetrics and Gynecology, Institute of Medical Education

Ksenia A. Rudenko

Almazov National Medical Research Center, Ministry of Health of the Russian Federation

Clinical Resident, Senior Laboratory Assistant, Department of Obstetrics and Gynecology

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