Diagnostic value of anthropometric characteristics of obesity in women during the menopause transition


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Abstract

Objective: To investigate the diagnostic performance of body mass index (BMI) to identify excess adipose tissue (AT) and compare the diagnostic value of anthropometric characteristics in detecting visceral obesity in women during the menopause transition (MT). Materials and methods: A total of 125 women (mean age 47.0 (2.7) years) undergoing the MT without obesity (BMI<30 kg/m²) participated in the study. Clinical evaluation included hormonal and metabolic profile, body composition measured by dual-energy X-ray absorptiometry (DEXA), and anthropometric measurements. Results: 35% of women with normal BMI and waist circumference (WC) <80 cm had excess AT associated with twice higher prevalence of dyslipidemia and insulin resistance. BMI≥25 kg/m² had a sensitivity of 59.6%, a specificity of 93.7%, and positive (PPV) and negative (NPV) predictive values of 94.4 and 56.6% in detecting excess AT. The ROC analysis determined an optimal threshold of BMI>22.5 kg/m² with a sensitivity of 92.9%, specificity of 68.7%, PPV 84.1%, and NPV 84.6%. ROC analysis of all anthropometric indices showed diagnostic significance (p<0.001) for detecting visceral obesity; WC had the highest AUC of 0.950 [95% CI 0.875-0.987]. Conclusion: In women undergoing the MT, it is reasonable to use more accurate methods of assessing obesity, such as the DEXA. A BMI≥25 kg/m² is not sufficiently informative to detect excess AT in women during MT. The optimal threshold for identifying women with excessive AT during MT is BMI>22.5 kg/m². Among anthropometric indices, WC has the highest diagnostic accuracy for detecting visceral obesity

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About the authors

Svetlana V. Yureneva

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology Ministry of Health of Russia

Email: syureneva@gmail.com
Dr. Med. Sci., Professor at the Department of Obstetrics and Gynecology of the Department of Vocational Education, Leading Researcher at the Department of Gynecologic Endocrinology

Veronika I. Komedina

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology Ministry of Health of Russia

Email: komedina.veronika@gmail.com
PhD. Student at the Department of Gynecologic Endocrinology

Sergey Yu. Kuznetsov

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology Ministry of Health of Russia

Email: kuznetsov.s@list.ru
Ph.D., Radiologist, Obstetrician-Gynecologist at the Department of Gynecologic Endocrinology

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