Earlyand late-onset fetal growth restriction: differential diagnosis based on proand antioxidant system markers
- Authors: Ganichkina M.B.1, Vysokikh M.Y.1, Tyutyunnik V.L.2, Chagovets V.V.1, Kan N.E.1,2
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Affiliations:
- Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
- European Medical Center Maternity Hospital
- Issue: No 9 (2020)
- Pages: 66-72
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/329524
- DOI: https://doi.org/10.18565/aig.2020.9.66-72
- ID: 329524
Cite item
Open Access
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Abstract
Objective. To investigate pro- and antioxidant system parameters in early- and late-onset fetal growth restriction. Materials and methods. The study included 82patients: the main group consisted of 41 women whose pregnancies were complicated by fetal growth restriction and the control group included 41 women without fetal growth restriction. The main group was divided into two subgroups. Subgroup Ia consisted of 20 pregnant women with early-onset fetal growth restriction (manifested before 34 weeks’ gestation), subgroup Ib included 21 patients with late-onset fetal growth restriction (manifested after 34 weeks’ gestation). Maternal plasma pro- and antioxidant system markers were evaluated using spectrophotometry, polarography and Western blot analysis. Results. A significant increase in oxidative stress level was observed in early-onset fetal growth restriction subgroup, whereas there was a decrease in late-onset fetal growth restriction subgroup compared to the controls. Logistic regression model was developed to differentiate early- and late-onset fetal growth restriction using maternal plasma pro- and antioxidant system parameters. Conclusion. Maternal plasma pro- and antioxidant system markers can be used in differential diagnosis of early-and late-onset fetal growth restriction after 34 weeks’ gestation.
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About the authors
Maria B. Ganichkina
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: mariaganichkina@yandex.ru
graduate student
Mikhail Yu. Vysokikh
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: m_vysokikh@oparina4.ru
PhD, the Head of mitochondrial medicine research group
Victor L. Tyutyunnik
European Medical Center Maternity Hospital
Email: tioutiounnik@mail.ru
PhD, MD, deputy head doctor
Vitaliy V. Chagovets
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: v_chagovets@oparina4.ru
PhD, senior researcher of Laboratory of Proteomics and Metabolomics of Human Reproduction, Department of Systems Biology in Reproduction
Natalia E. Kan
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia; European Medical Center Maternity Hospital
Email: kan-med@mail.ru
PhD, MD, head doctor of the Perinatal Center of European Medical Center, Professor of the Department of Obstetrics and Gynecology
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