Pregnancy is a natural model of metabolic syndrome: results of a dynamic study of physiological gestation


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Abstract

Objective. To identify the tendency for changes in carbohydrate, lipid metabolism, angiogenic, hormonal, hematological, inflammatory parameters and clarify what ‘normal pregnancy’ is in terms of fetal life support based on the monitoring of patients with uncomplicated pregnancy. Materials and methods. This was a comprehensive dynamic study of 40 healthy women with normal gestation and 30 healthy non-pregnant women. Results. Insulin resistance and compensatory hyperinsulinemia, hyperleptinemia, atherogenic lipid profile, pro-inflammatory, pro-angiogenic and hypercoagulable state, sympathicotonia, hyperuricemia, visceral type accumulation, and endothelial-platelet interaction can develop in normal pregnancy. Conclusion. Changes in normal pregnancy are aimed at the life support of the fetus with adverse atherogenic and diabetogenic changes in the maternal metabolism. The parameters of normal pregnancy are similar to the functional phase of the metabolic syndrome; thus, one can draw a conclusion that pregnancy is a natural model of the metabolic syndrome.

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About the authors

Igor S. Lipatov

Samara State Medical University, Ministry of Health of Russia

Email: i.lipatoff2012@yandex.ru
MD, professor, professor of obstetrics and gynecology chair number 1

Yury V. Tezikov

Samara State Medical University, Ministry of Health of Russia

Email: yra.75@inbox.ru
MD, professor, Head of obstetrics and gynecology chair number 1

Roman G. Shmakov

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: mdshmakov@mail.ru
MD, RAS Professor, chief medical officer

Amir R. Azamatov

Samara State Medical University, Ministry of Health of Russia

Email: azamatov.amir@yandex.ru
resident of obstetrics and gynecology chair number 1

Nadezhda V. Martynova

Samara State Medical University, Ministry of Health of Russia

Email: og1samsmu@mail.ru
teaching assistant of obstetrics and gynecology chair number 1

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