Complex of clinical symptoms in reproductiveaged women with aplasia of the vagina and uterus


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Abstract

Objective. To describe the complex of clinical symptoms in reproductive-aged patients with aplasia of the vagina and uterus on the basis of retrospective and prospective analysis. Materials and methods. The study included 406 patients with aplasia of the uterus and vagina. The average age of patients was 20-24 years in 67.2% of cases, and there were 31.2% of cases of patients under 19 years of age. Subgroup I consisted of364patients with aplasia of the vagina and uterus and non-functioning rudiments, subgroup II included 42 patients with aplasia of the vagina and uterus and functioning rudiments. The patients without malformations of the genitals were enrolled in the control group (n=47). The analysis of patient’s case history, physical and clinical examination, surgical treatment, and immunohistochemical examination of the removed functioning rudiments was carried out. Results. The patients were found to have a high level of stigmatization. Malformations of the urinary system were detected in 40.1% of cases, diseases of the urinary system resulting from urodynamic disorders in 18.9% of cases, pathology of the musculoskeletal system in 17.9% of cases, diseases of the gastrointestinal tract in 19.5%, diseases of the eyes in 8.8%, congenital heart diseases in 7.7-8.1%, etc. Colpopoiesis from the pelvic peritoneum using minimally invasive technologies is the main surgical intervention in patients with aplasia of the uterus and vagina. All girls with aplasia of the vagina and uterus who had a history of inguinal hernias should be examined for karyotype. Conclusion. The patients with aplasia of the vagina and uterus have a higher rate of malformations of other organs and systems, which is suggestive of impaired embryogenesis. Dysregulation pathology prevails in patients with aplasia of the vagina and uterus in case of functioning rudiments. Functioning uterine rudiments may be subjected to the same pathological processes as the normal uterus (fibroids, endometriosis).

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About the authors

Marina V. Bobkova

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: m_bobkova@oparina4.ru,morskoisapfir@rambler.ru
PhD, practical doctor of Operative Gynecology Department

Tatjyana Yu. Smolnova

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: smoltat@list.ru
MD, Senior Research Associate of Surgery Department

Nafisa M. Fayzullina

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: naflsa.fayzullina@gmail.com
PhD, Senior Research Associate of Laboratory of Pathological Anatomy

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