PRIMARY HYPERPARATHYROIDISM AND PREGNANCY


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Abstract

Objective. To present an update on calcium metabolism during pregnancy, as well as on the epidemiology, clinical picture, diagnosis, and treatment of primary hyperparathyroidism during pregnancy. Material and methods. Available literature sources published in the databases Medline, PubMed, and others were sought. 65 sources dealing with the study of phosphorus and calcium metabolism and with the course of primary hyperparathyroidism during pregnancy were found; 55 of them were included in this review. Results. The paper gives the data available in the literature on changes in phosphorus and calcium metabolism during pregnancy and on the course of primary hyperparathyroidism during pregnancy. Conclusion. Primary hyperparathyroidism is associated with the high risk of complications in the mother and her child and with high mortality rates. Early diagnosis and the choice of optimal tactics are priority in this patient group.

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About the authors

Natalia G. Mokrysheva

Endocrinology Research Center, Ministry of Health of Russia

Email: nm70@mail.ru
MD, director of the Center for parathyroid pathology Moscow 117036, Dmitry Ulyanov str. 11, Russia

Anna K. Lipatenkova

Endocrinology Research Center, Ministry of Health of Russia

Email: parathyroid.enc@gmail.com
researcher at the Center parathyroid pathology Moscow 117036, Dmitry Ulyanov str. 11, Russia

Nikita A. Taller

Institute of Plastic Surgery and Cosmetology

Email: nicktaller@gmail.com
endocrinologist Moscow 105066, Olkhovskaya str. 27, Russia

References

  1. Мокрышева Н.Г., Дедов И.И., Васильева Т.О., Рожинская Л.Я. Эпидемиология первичного гиперпаратиреоза. Проблемы эндокринологии. 2010; 56(5): 3-7.
  2. Schnatz P.F., Curry S.L. Primary hyperparathyroidism in pregnancy: evidence-based management. Obstet. Gynecol. Surv. 2002; 57(6): 365-76.
  3. Dahlman T., Sjöberg H.E., Bucht E. Calcium homeostasis in normal pregnancy and puerperium. A longitudinal study. Acta Obstet. Gynecol. Scand. 1994; 73(5): 393-8.
  4. Hacker A.N., Fung E.B., King J.C. Role of calcium during pregnancy: maternal and fetal needs. Nutr. Rev. 2012; 70(7): 397-409.
  5. Судаков Д.С., Зазерская И.Е., Галкина О.В., Богданова Е.О. Дозозависимый эффект влияния потребления кальция на фосфорно-кальциевый и костный обмен при беременности. Остеопороз и остеопатии. 2010; 2: 7-11.
  6. Khosla S., van Heerden J.A., Gharib H., Jackson I.T., Danks J., Hayman J.A., Martin T.J. Parathyroid hormone-related protein and hypercalcemia secondary to massive mammary hyperplasia. N. Engl. J. Med. 1990; 322(16): 1157.
  7. O’Brien K.O., Nathanson M.S., Mancini J., Witter F.R. Calcium absorption is significantly higher in adolescents during pregnancy than in early postpartum period. Am. J. Clin. Nutr. 2003; 78(6): 1188-93.
  8. Kovacs C.S., Chafe L.L., Woodland M.L., McDonald K.R., Fudge N.J., Wookey P.J. Calcitropic gene expression suggests a role for the intraplacental yolk sac in maternal-fetal calcium exchange. Am. J. Physiol. Endocrinol. Metab. 2002; 282(3): E721-32.
  9. Brown J.L., Burton D.W., Deftos L.J., Smith A.A., Pincus D.W., Haller M.J. Congenital craniopharyngioma and hypercalcemia induced by parathyroid hormone-related protein. Endocr. Pract. 2007; 13: 67-71.
  10. Kovac C.S., Fuleihan G. Calcium and bone disorders during pregnancy and lactation. Endocrinol. Metab. Clin. North Am. 2006; 35: 21-51.
  11. Parkes I., Schenker J.G., Shufaro Y. Parathyroid and calcium metabolism disorders during pregnancy. Gynecol. Endocrinol. 2013; 29(6): 515-9.
  12. Kovacs C.S., Lanske B., Hunzelman J.L., Guo J., Karaplis A.C., Kronenberg H.M. Parathyroid hormone-related peptide (PTHrP) regulates fetal-placental calcium transport through a receptor distinct from the PTH/PTHrP receptor. Proc. Natl. Acad. Sci. USA. 1996; 93(26): 15233-8.
  13. Seely E.W., Brown E.M., DeMaggio D.M., Weldon D.K., Graves S.W. A prospective study of calciotropic hormones in pregnancy and postpartum: reciprocal changes in serum intact parathyroid hormone and 1,25-dihydroxyvitamin D. Am. J. Obstet. Gynecol. 1997; 176(1, Pt 1): 214-7.
  14. Ritchi L.D., King J.C. Dietary calcium and pregnancy induce hypertension: is there a relation? Am. J. Clin. Nutr. 2000; 71(5): 1371-4.
  15. Щербавская Э.А., Кочеткова Е.А., Гельцер Б.И. Кальций-D3 никомед в профилактике остеопенических осложнений у беременных с гестозами. Гинекология. 2002; 4(1): 12-6
  16. Prentice A. Maternal calcium metabolism and bone mineral status. Am. J. Clin. Nutr. 2000; 71(5): 1312-6.
  17. Singht H.J., Mohammad N.H., Nila A. Serum calcium and parathormone during normal pregnancy in Malay women. J. Matern. Fetal Med. 1999; 8(3): 95-100.
  18. Ammann P., Irion O., Gast J., Bonjour J.P., Beguin F., Rizzoli R. Alterations of calcium and phosphate metabolism in primary hyperparathyroidism during pregnancy. Acta Obstet. Gynecol. Scand. 1993; 72(6): 488-92.
  19. Fisher D.A. Endocrinology of fetal development. In: Larsen P.R., Kronenberg H.M., Melmed S., Polonsky M.D., eds. Williams textbook of endocrinology. 10th ed. Saunders; 2003: 811-41.
  20. Gagel R.F. Laboratory values of importance for calcium metabolism and metabolic bone disease. In: Favus M., ed. Primer on the metabolic bone diseases and disorders of mineral metabolism. 2nd ed. New York: Raven Press; 1993: 411-512.
  21. Ong G.S., Walsh J.P, Stuckey B.G., Brown S.J., Rossi E., Ng J.L. et al. The importance of measuring ionized calcium in characterizing calcium status and diagnosing primary hyperparathyroidism. J. Clin. Endocrinol. Metab. 2012; 97(9): 3138-45.
  22. Norman J., Politz D., Politz L. Hyperparathyroidism during pregnancy and the effect of rising calcium on pregnancy loss: a call for earlier intervention. Clin. Endocrinol. (Oxf.). 2009; 71(1): 104-9.
  23. Soto G.D., Halperin I., Squarcia M., Lomena F., Domingo M.P. Update in thyroid imaging. The expanding world of thyroid imaging and its translation to clinical practice. Hormones (Athens). 2010; 9(4): 287-98.
  24. Whitson B.A., Broadie T.A. Preoperative ultrasound and nuclear medicine studies improve the accuracy in localization of adenoma in hyperparathyroidism. Surg. Today. 2008; 38(2): 222-6.
  25. McMullen T.P., Learoyd D.L., Williams D.C., Sywak M.S., Sidhu S.B., Delbridge L. W. Hyperparathyroidism in pregnancy: options for localization and surgical therapy. World J. Surg. 2010; 34(8): 1811-6.
  26. Yu N., Donnan P.T., Murphy M.J., Leese G.P. Epidemiology of primary hyperparathyroidism in Tayside, Scotland, UK. Clin. Endocrinol. (Oxf.). 2009; 71(4): 485-93.
  27. Marcocci C., Cetani F Clinical practice. Primary hyperparathyroidism. N. Engl. J. Med. 2011; 365(25): 2389-97.
  28. Carella J., Gossain V.V. Hyperparathyroidism and pregnancy: case report and review. J. Gen. Intern. Med. 1992; 7(4): 448-53.
  29. Schnatz P-F., Thaxton S. Parathyroidectomy in the third trimester of pregnancy. Obstet. Gynecol. Surv. 2005; 60(10): 672-82.
  30. Hong M.K., Hsieh C.T., Chen B.H., Tu S.T., Chou P.H. Primary hyperparathyroidism and acute pancreatitis during the pregnancy. J. Matern. Fetal Med. 2001; 10(3): 214-8.
  31. Dahan M., Chang R.J. Pancreatitis secondary to hyperparathyroidism during pregnancy. Obstet. Gynecol. 2001; 98(5, Pt 2): 923-5.
  32. Diaz-Soto G., Linglart A., Sénat M.V., Kamenicky P., Chanson P. Primary hyperparathyroidism in pregnancy. Endocrine. 2013; 44(3): 591-7.
  33. Hultin H., Heilman P., Lundgren E., Olovsson M., Ekbom A., Rastad J., Montgomery S.M. Association of parathyroid adenoma and pregnancy with preeclampsia. J. Clin. Endocrinol. Metab. 2009; 94(9): 3394-9.
  34. Truong M.T., Lalakea M.L., Robbins P., Friduss M. Primary hyperparathyroidism in pregnancy: a case series and review. Laryngoscope. 2008; 118(11): 1966-9.
  35. Shangold M.M., Dor N., Welt S.I. Hyperparathyroidism and pregnancy: a review. Obstet. Gynecol. Surv. 1982; 37(4): 217-28.
  36. Potts J.T. Jr. Diseases of the parathyroid gland and other hyper- and hypocalcemic disorders. In: Kasper D.L., Jameson J.L., Braunwald E., Fauci A.S., Hauser S.L., Longo D.L. Harrison’s principles of internal medicine. 16th ed. McGraw-Hill Med. Publ.; 2004.
  37. Malekar-Raikar S., Sinnott B.P. Primary hyperparathyroidism in pregnancy-a rare cause of life-threatening hypercalcemia: case report and literature review. Case Rep. Endocrinol. 2011; 2011; 520516.
  38. Ip P. Neonatal convulsion revealing maternal hyperparathyroidism: an unusual case of late neonatal hypoparathyroidism. Arch. Gynecol. Obstet. 2003; 268(3): 227-9.
  39. Kokrdova Z. Pregnancy and primary hyperparathyroidism. J. Obstet. Gynaecol. 2010; 30(1): 57-9.
  40. Cemeroglu A.P., Böber E., Büyükgebiz A. Prolonged hypocalcemia in a 2 month-old boy unmasking maternal diagnosis of primary hyperparathyroidism. J. Pediatr. Endocrinol. Metab. 2001; 14(6): 785-7.
  41. Kelly T.R. Primary hyperparathyroidism during pregnancy. Surgery. 1991; 110(6): 1028-34.
  42. Kristoffersson A., Dahlgren S., Lithner F., Järhult J. Primary hyperparathyroidism in pregnancy. Surgery. 1985; 97(3): 326-30.
  43. Trebb C., Wallace S., Ishak F., Splinter K.L. Concurrent parathyroidectomy and caesarean section in the third trimester. J. Obstet. Gynaecol. Can. 2014; 36(6): 502-5.
  44. Conzo G., Perna A., Avenia N., De Santo R.M., Della Pietra C. Evaluation of the ‘putative’ role of intraoperative intact parathyroid hormone assay during parathyroidectomy for secondary hyperparathyroidism. A retrospective study on 35 consecutive patients: intraoperative iPTH assay during parathyroidectomy. Endocrine. 2012; 42(3): 606-11.
  45. Kebebew E., Hwang J., Reijf E., Duh Q.Y., Clark O.H. Predictors of single-gland vs. multigland parathyroid disease in primary hyperparathyroidism: a simple and accurate scoring model. Arch. Surg. 2006; 141(8): 777-82.
  46. Udelsman R., Pasieka J.L., Sturgeon C., Young J.E., Clark O.H. Surgery for asymptomatic primary hyperparathyroidism: proceedings of the third international workshop. J. Clin. Endocrinol. Metab. 2009; 94(2): 366-72.
  47. Rolighed L., Bollerslev J., Mosekilde L. Vitamin D treatment in primary hyperparathyroidism. Curr. Drug Saf. 2011; 6(2): 100-7.
  48. Witteveen J.E., van Thiel S., Romijn J.A., Hamdy N.A. Hungry bone syndrome: still a challenge in the post-operative management of primary hyperparathyroidism: a systematic review of the literature. Eur. J. Endocrinol. 2013; 168(3): R45-53.
  49. Asghar A., Ikram M., Islam N. A case report: Giant cystie parathyroid adenoma presenting with parathyroid crisis after Vitamin D replacement. BMC Endocr. Disord. 2012; 12(1): 14.
  50. Krysiak R., Wilk M., Okopien B. Recurrent pancreatitis induced by hyperparathyroidism in pregnancy. Arch. Gynecol. Obstet. 2011; 284(3): 531-4.
  51. Levy S., Fayez I., Taguch N., Han J. Y., Aiello J., Matsui D. et al. Pregnancy outcome following in utero exposure to bisphosphonates. Bone. 2009; 44(3): 428-30.
  52. Silverberg S.J., Rubin M.R., Faiman C., Peacock M., Shoback D.M., Smallridge R.C. et al. Cinacalcet hydrochloride reduces the serum calcium concentration in inoperable parathyroid carcinoma. J. Clin. Endocrinol. Metab. 2007; 92(10): 3803-8.
  53. SENSIPAR (cinacalcet hydrochloride). Available at: http://dailymed.nlm. nih.gov/dailymed/lookup.cfm?setid=45028573-13c4-4c8b-ae62-6c75bba97c81 Accessed 21.04.14.
  54. Horjus C., Groot I., Telting D., van Setten P., van Sorge A., Kovacs C.S. et al. Cinacalcet for hyperparathyroidism in pregnancy and puerperium. J. Pediatr. Endocrinol. Metab. 2009; 22(8): 741-9.
  55. Nadarasa K., Bailey M., Chahal H., Raja O., Bhat R., Gayle C. et al. The use of cinacalcet in pregnancy to treat a complex case of parathyroid carcinoma. Endocrinol. Diabetes Metab. Case Rep. 2014; 2014: 140056.

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