MASTOPATHY: PATHOGENESIS AND A POSSIBILITY OF CORRECTION
- Authors: Musina E.V.1, Kogan I.Y.1
-
Affiliations:
- D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
- Issue: No 10 (2016)
- Pages: 33-38
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/329696
- DOI: https://doi.org/10.18565/aig.2016.10.33-8
- ID: 329696
Cite item
Open Access
Access granted
Abstract
Objective. To analyze the data available in modern literature and the results of the authors’ investigations dealing with the mechanisms of mastopathy and with a possibility of its pathogenetic treatment. Material and methods. The review gives the data Russian and foreign studies on the role of sex steroid hormones and the activity of breast cell proliferation and apoptosis in the development of mastopathy and its proliferative forms in particular. Results. Ovarian dysfunction and a change in breast tissue susceptibility to ovarian steroid hormones are associated with the activation of mammary epithelial cell proliferation in patients with mastopathy. There is evidence that the combination drug mammoklam may have a suppressive effect on the activity of breast cell proliferation, which is associated with the favorable effect of the drug on the clinical presentation of the disease. Conclusion. The agents used to treat mastopathy may include the combination drug mammoklam that affects the key points of the pathogenesis of the disease.
Keywords
Full Text
About the authors
Ekaterina V. Musina
D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
Email: e.musina@mail.ru
MD, obstetrician-gynecologist, head of educational and methodical department Saint Petersburg 199034, Mendeleev line 3, Russia
Igor Yu. Kogan
D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
Email: ikogan@mail.ru
PhD, MD, professor, scientific secretary Saint Petersburg 199034, Mendeleev line 3, Russia
References
- Летягин В.П. Первичные опухоли молочной железы. М.: Миклош; 2004. 332с.
- Летягин В.П. Мастопатия. Русский медицинский журнал. 2000; 8(11): 468-72.
- Коган И.Ю., Мясникова М.О. Диагностика и лечение мастопатии. СПб.; 2010. 31с.
- Коган И.Ю. Гиперпластические процессы в молочных железах у женщин (патогенез, прогнозирование течения): автореф. дисс.. д-ра мед. наук. СПб.; 2008. 35с.
- Clarke C.L., Sutherland R.L. Progestin regulation of cellular proliferation. Endocr. Rev. 1990; 11(2): 266-301.
- Clarke R.B. Steroid receptors and proliferation in the human breast. Steroids. 2003; 68(10-13): 789-94.
- Smith R.L., Pruthi S., Fitzpatrick L.A. Evaluation and management of pain. Mayo Clin. Proc. 2004; 79(3): 353-72.
- Tung L., Abdel-Hafiz H., Shen T., Harvell D.M., Nitao L.K., Richer J.K. et al. Progesterone receptors PR-B and PR-A regulate transcription by different mechanisms: AF-3 exerts regulatory control over coactivator binding to PR-B. Mol. Endocrinol. 2006; 20(11): 2656-70.
- Gompel A., Chaouat M., Hugol D., Forgez P. Steroidal hormones and proliferation, differentiation and apoptosis in breast cells. Maturitas. 2004; 49(1):16-24.
- Going J.J., Anderson T.J., Battersby S., MacIntyre C.C. Proliferative and secretory activity in human breast during natural and artificial menstrual cycles. Am. J. Pathol. 1988; 130(1): 193-204.
- Soyal S., Ismail P.M., Li J., Mulac-Jericevic B., Conneely O.M., Lydon J.P. Progesterone’s role in mammary gland development and tumorigenesis as disclosed by experimental mouse genetics. Breast Cancer Res. 2002; 4(5): 191-6.
- Graham J.D., Yeates C., Balleine R.L., Harvey S.S., Milliken J.S., Bilous A.M., Clarke C.L. Progesterone receptor A and В protein expression in human breast cancer. J. Steroid Biochem. Mol. Biol. 1996; 56(1-6, Spec. No): 93-8.
- Li S., Han B., Liu G., Li S., Ouellet J., Labrie F., Pelletier G. Immunocytochemical localization of sex steroid hormone receptors in normal human mammary gland. J. Histochem. Cytochem. 2010; 58(6): 509-15.
- Simoncini T., Mannella P., Fornari L., Caruso A., Varone G., Genazzani A.R. In vitro effects of progesterone and progestins on vascular cells. Steroids. 2003; 68(10-13): 831-6.
- Kariagina A., Aupperlee M.D., Haslam S.Z. Progesterone receptor isoforms and proliferation in the rat mammary gland during development. Endocrinology. 2007; 148(6): 2723-36.
- Vazquez F., Rodríguez-Manzaneque J.C., Lydon J.P., Edwards D.P., O’Malley B.W., Iruela-Arispe M.L. Progesterone regulates proliferation of endothelial cells. J. Biol. Chem. 1999; 274(4): 2185-92.
- Conneely О.М., Mulac-Jericevic B., Lydon J.P. Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms. Steroids. 2003; 68(10-13): 771-8.
- Branchini G., Schneider L., Cericatto R., Capp E., Brum I.S. Progesterone receptors A and B and estrogen receptor alpha expression in normal breast tissue and fibroadenomas. Endocrine. 2009; 35(3): 459-66.
- Foidart J.M., Colin C., Denoo X., Desreux J., Béliard A., Fournier S., de Lignières B. Estradiol and progesterone regulate the proliferation of human breast epithelial cells. Fertil. Steril. 1998; 69(5): 963-9.
Supplementary files
