DEVELOPMENT OF THE REPRODUCTIVE SYSTEM IN GIRLS LIVING IN AN AREA EXPOSED TO HORMONE-LIKE XENOBIOTICS


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Abstract

Objective. To evaluate the physical and sexual development of girls living in an area exposed to organochlorine pesticides during their pubescence. Subjects and methods. Examinations were made in 524 girls aged 10-17 years, of whom 253 girls lived in a cotton-growing area (a study group) and 271 girls in an area where the leading industry was animal husbandry (a control group). They underwent anthropometric measurements, assessment of the development of secondary sex characteristics, and determination of the peripheral blood levels of gonadotropic and steroid hormones, organochlorine pesticides, and insulin-like growth factor 1. Results. There was retarded physical and sexual development, as well as the decreased level of gonadotropic hormones and estradiol, and insulin-like growth factor 1, which correlated with the increased blood content of pesticides in girls living in the area exposed to hormone-like xenobiotics. Conclusion. The girls living in the area exposed to hormone-like xenobiotics belong to a group at risk for reproductive dysfunction.

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About the authors

Gauri Billakhanovna Bapayeva

Branch, University Medical Center Corporate Fund, National Research Center for Maternity and Childhood

Email: gauri@inbox.ru
MD, associate professor, Head of Obstetrics and Gynecology Department Astana 010000, Turan av. 32, Kazakhstan

Akmaral Rakhmattulaevna Zhumadilova

H.A. Yasawi International Kazakh-Turkish University

Email: akusheria.medisina2@mail.ru
Obstetrics and Gynecology Department Turkestan, Sattarhanov str. 29, South region, Kazakhstan

Raushan Gabbasovna Nurchasimova

H.A. Yasawi International Kazakh-Turkish University

Email: akusheria.medisina2@mail.ru
Candidate of medical Sciences, associate professor Turkestan, Sattarhanov str. 29, South region, Kazakhstan

Saltanat Nalibekkyzy Kulbayeva

South-Kazakhstan State Medical Academy

Email: saltanat_phd@mail.ru
PhD, the Department of Primary health care with obstetrics and gynecology course Shymkent, Al-Farabi Square 1, South Kazakhstan Region, Kazakhstan

Renata Tleuzhanovna Tleuzhan

South-Kazakhstan State Medical Academy

Email: tleuzhan76@mail.ru
Candidate of medical Sciences, the Department of Primary health - care with obstetrics and gynecology course Shymkent, Al-Farabi Square 1, South Kazakhstan Region, Kazakhstan

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