IMPACT OF MAGNESIUM DEFICIENCY ON THE COURSE OF CLIMACTERIC SYNDROME


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Abstract

Objective. To estimate the prevalence of magnesium deficiency (MD) and the characteristics of clinical symptoms in women with climacteric syndrome (CS) and to determine the efficacy of Magne B6 forte in improving the quality of life in patients. Subjects and methods. A total of 3808 women with climacteric syndrome were examined. In the first phase of the study, the symptoms of CS and the prevalence of MD were assessed using the standardized Mood Disorder Questionnaire (MDQ) and/or serum magnesium levels were measured. The quality of life in the women with CS was estimated according to the WHOQOL-BREF questionnaire. In the second step, the patients with MD were treated with a magnesium citrate-containing drug for 4 weeks; the therapeutic efficiency was evaluated. Results. The high prevalence of MD was noted in the patients with CS (60%). The clinical efficacy of Magne B6 forte was confirmed by an increase in serum magnesium levels (from 0.67±0.09 to 0.80±0.25mmol/l;p < 0.001), normalization of MDQ scores (from 43.4±11.9 to 24.0±14.9; p < 0.001), a reduction in the severity of more than half of the CS symptoms by 2-2.5 times, and an improvement in quality of life. Conclusion. The use of Magne B6 forte in patients with CS contributes to improvements in the course of the disease and in the quality of life.

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About the authors

Aleksandr D. Makatsariya

I.M. Sechenov First Moscow State Medical University

Email: gemostasis@mail.ru
RAS corresponding member, DM, Professor, Head of obstetrics and gynecology department, Head of hemostasis pathology laboratory Moscow 119992, Malaya Trubetskaya str. 8 bld. 2, Russia

Galina B. Dikke

Peoples' Friendship University of Russia

Email: galadikke@yandex.ru
Honored Scientist and Education Worker, DM, Professor of the Department of Obstetrics, Gynecology and Reproductive Medicine, Faculty of Advanced Training of Medical Workers Moscow 117198, Miklukho-Maklaya str. 8, Russia

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