Potentials of the current pharmacotherapy of endometriosis

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Abstract

Endometriosis is a chronic polyetiological disease characterized by the presence of endometrial-like tissue outside the uterine cavity. The known symptoms of endometriosis include the following: dysmenorrhea, dyspareunia, dysuria, dyschezia, chronic pelvic pain, and infertility. Postoperative endometriosis recurrences are known to occur in approximately 50% of patients within 5 years in the absence of postoperative suppressive treatment. The paper describes different groups of drugs (gonadotropin-releasing hormone agonists and antagonists, progestogens, combined hormonal contraceptives, dopamine agonists, and metformin) for the treatment of endometriosis, their mechanism of action, and their efficacy in relieving chronic pelvic pain, preventing endometriosis recurrences, side effects, and the impact on quality of life.

Conclusion: Taking into account the chronic nature of the disease, today it is important to find effective drugs with a minimum number of side effects, which will relieve pain syndrome and reduce the frequency of surgical re-interventions and endometriosis relapses.

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Madina R. Dumanovskaya

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Author for correspondence.
Email: m_dumanovskaya@oparina4.ru
ORCID iD: 0000-0001-7286-6047

PhD, Researcher, Gynecological Endocrinology Department

Russian Federation, Moscow

Guzal I. Tabeeva

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: g_tabeeva@oparina4.ru
ORCID iD: 0000-0003-1498-6520

PhD, Senior Researcher, Gynecological Endocrinology Department

Russian Federation, Moscow

Julia A. Ivannikova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia

Email: ivannikova0@yandex.ru

physician, resident

Russian Federation, Moscow; Moscow

Alina E. Solopova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_solopova@oparina4.ru
ORCID iD: 0000-0003-4768-115X

Dr. Med. Sci., Associate Professor, Leading Researcher, Department of Radiology

Russian Federation, Moscow

Aleksandra V. Asaturova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_asaturova@oparina4.ru
ORCID iD: 0000-0001-8739-5209

Dr. Med. Sci., Head of 1st Pathology Department

Russian Federation, Moscow

Antonina A. Smetnik

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_smetnik@oparina4.ru
ORCID iD: 0000-0002-0627-3902

PhD, Head of the Department of Gynecological Endocrinology

Russian Federation, Moscow

Patimat M. Alieva

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: patimat.alieva.1997@bk.ru

obstetrician-gynecologist, postgraduate student at the Department of Gynecological Endocrinology

Russian Federation, Moscow

Elena I. Ermakova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_ermakova@oparina4.ru
ORCID iD: 0000-0002-6629-051X

PhD, Senior Researcher at the Department of Gynecological Endocrinology

Russian Federation, Moscow

Stanislav V. Pavlovich

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia

Email: s_pavlovich@oparina4.ru
ORCID iD: 0000-0002-1313-7079

Ph.D., Academic Secretary; Professor, Department of Obstetrics, Gynecology, Perinatology and Reproductology

Russian Federation, Moscow; Moscow

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