Quality of life in patients with premature ovarian insufficiency treated with hormone replacement therapy
- Authors: Averkova V.G.1, Yureneva S.V.1
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Affiliations:
- Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
- Issue: No 5 (2023)
- Pages: 50-58
- Section: Original Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/516556
- DOI: https://doi.org/10.18565/aig.2023.16
- ID: 516556
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Abstract
Objective: To compare the quality of life (QoL) between patients with premature ovarian insufficiency (POI) treated with hormone replacement therapy (HRT) and women with preserved ovarian function.
Materials and methods: This cross-sectional study of 374 patients was conducted at V.I. Kulakov NMRC for OG&P, Ministry of Health of Russia. Group 1 included 223 patients with POI who received HRT, and group 2 included 151 patients with preserved ovarian function. Quality of life was assessed using the Health Status Survey (SF-36), which was validated for use in Russia.
Results: Patients in group 1 had statistically significant differences in all eight domains of the SF-36 questionnaire compared with those in group 2 (p<0.0007, p<0.0001). The lowest scores in group 1 were on the VT (Vitality) scale at 43.3 (18.3), GH (General Health) at 40.1 (18.0), and RP (Role Physical) at 46.6 (34.8). POI was associated with an 18% (1.21 times) decrease in the mean score of the integral measures of the physical and mental health components of the patients compared to the control group. Patients in group 1 were 3.06 times less likely (95% CI 2.39–3.92) to have a score above the normal 50-point threshold for the physical component of health, and 4.43 times less likely (95% CI 2.96–6.63) to have a score above the mental component of health than those in group 2. The QoL of POI patients was directly related to the estradiol (E2) dose in HRT; an increase in the E2 dose was associated with higher scores on most SF-36 measures.
Conclusion: POI has long-term adverse effects on all components of health and reduces QoL. HRT with standard doses of E2 in POI patients often fails to provide a QoL comparable to that of women of the same age with preserved ovarian function. Prescribing adequate doses of HRT, using an individualized approach and a multidisciplinary team to manage patients with POI, can significantly improve quality of life and outcomes.
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About the authors
Victoria G. Averkova
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
Author for correspondence.
Email: buch1202@mail.ru
ORCID iD: 0000-0002-8584-5517
PhD Student of Gynecological Endocrinology Department
Russian Federation, MoscowSvetlana V. Yureneva
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
Email: syureneva@gmail.com
ORCID iD: 0000-0003-2864-066X
Dr. Med. Sci., Professor at the Department of Obstetrics and Gynecology of the Department of Vocational Education; Deputy Director for Science of the Institute of Oncogynecology and Mammology
Russian Federation, MoscowReferences
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