The role of fatty acid synthase in the development of fetal macrosomia in women with gestational diabetes mellitys and threatened late miscarriage in the second trimester of pregnancy

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Abstract

Currently, there has been an increased incidence of macrosomia, that negatively affects newborn’s future life and health. There is no data in literature on the effect of serum fatty acid synthase (FAS) on threatened miscarriage in women with gestational diabetes mellitus (GDM). Serum FAS concentrations have not been previously assessed to predict macrosomia.

Objective: To compare serum FAS concentrations between women with GDM and threatened miscarriage that was diagnosed in the second trimester of pregnancy and women without GDM and with threatened miscarriage that was diagnosed in the second trimester.

Materials and methods: The main group included 25 patients with GDM and miscarriage, diagnosed in the second trimester of pregnancy. The comparison group consisted of 30 women with miscarriage diagnosed in the second trimester of pregnancy.

Results: The number of microsomic babies was higher in the main group versus the comparison group (15/25 (60.0%), 4/30 (13.33%), p=0.002). Serum concentrations in women in the main group was higher (1.64 ng/ml (1.13; 1.98); 0.8 ng/ml (0.3075; 1.55); p<0.001). The comparison between pregnant women with fetal macrosomia and women without fetal macrosomia showed high diagnostic ROC AUC value=0.867 (95% CI 0.67–0.96). Sensitivity was 87.5% (95% CI 70.3–93.4), specificity was 88.9% (95% CI 58.3–99.4), the prognostic value of positive results was 93.3% (95% CI 75.0–99.6), and the prognostic value of negative results was 80.0% (95% CI 52.5–89.5).

Conclusion: It is probable that detection of serum FAS concentration can be considered as a promising method for prediction of macrosomia. However further studies are necessary in this area.

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About the authors

Anna I. Malyshkina

Ivanovo Research Institute of Maternity and Childhood named after V.N. Gorodkov, Ministry of Health of Russia; Ivanovo State Medical Academy, Ministry of Health of Russia

Author for correspondence.
Email: ivniimid@inbox.ru
ORCID iD: 0000-0002-1145-0563

Dr. Med. Sci., Professor, Director, V.N. Gorodkov Ivanovo Research Institute of Motherhood and Childhood, Ministry of Health of the Russian Federation; Head of the Department of Obstetrics and Gynecology, Medical Genetics, Ivanovo State Medical Academy, Ministry of Health of the Russian Federation

Russian Federation, Ivanovo; Ivanovo

Natalya Yu. Sotnikova

Ivanovo Research Institute of Maternity and Childhood named after V.N. Gorodkov, Ministry of Health of Russia; Ivanovo State Medical Academy, Ministry of Health of Russia

Email: ivniimid@inbox.ru
ORCID iD: 0000-0002-0608-0692

Dr. Med. Sci., Professor, Honored Doctor of the Russian Federation, Head of the Laboratory of Clinical Immunology, V.N. Gorodkov Ivanovo Research Institute of Motherhood and Childhood, Ministry of Health of the Russian Federation; Professor, Department of Pathophysiology and Immunology, Ivanovo State Medical Academy, Ministry of Health of the Russian Federation

Russian Federation, Ivanovo; Ivanovo

Natalya V. Kroshkina

Ivanovo Research Institute of Maternity and Childhood named after V.N. Gorodkov, Ministry of Health of Russia

Email: ivniimid@inbox.ru

PhD, Researcher

Russian Federation, Ivanovo

Nataliya V. Batrak

Ivanovo State Medical Academy, Ministry of Health of Russia

Email: batrakn@inbox.ru
ORCID iD: 0000-0002-5230-9961

PhD, Associate Professor at the Department of Obstetrics and Gynecology, Medical Genetics

Russian Federation, Ivanovo

Viktorija A. Afonina

Ivanovo Research Institute of Maternity and Childhood named after V.N. Gorodkov, Ministry of Health of Russia; Ivanovo State Medical Academy, Ministry of Health of Russia

Email: ezhevika23023@yandex.ru
ORCID iD: 0000-0002-3145-5679

PhD Student, V.N. Gorodkov Ivanovo Research Institute of Motherhood and Childhood, Ministry of Health of the Russian Federation; Teaching Assistant, Ivanovo State Medical Academy, Ministry of Health of the Russian Federation

Russian Federation, Ivanovo; Ivanovo

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2. Figure. Serum FAS concentration in pregnant women with GDM and threatened miscarriage diagnosed in the second trimester of pregnancy

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