Experience with bovhyaluronidase azoximer used in the combination treatment of chronic endometritis in women with repeated implantation failures
- Authors: Lokshin V.N.1, Askar Y.1,2, Rybina A.N.1,2, Abshekenova A.T.1,2, Karibayeva S.K.1,2, Valiev R.K.1
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Affiliations:
- “PERSONA” International Clinical Center of Reproductology
- Asfendiyarov Kazakh National Medical University
- Issue: No 5 (2023)
- Pages: 108-112
- Section: Exchange of Experience
- URL: https://journals.eco-vector.com/0300-9092/article/view/516581
- DOI: https://doi.org/10.18565/aig.2023.119
- ID: 516581
Cite item
Abstract
Objective: To evaluate the efficiency of using bovhyaluronidase azoximer in the combination treatment of chronic endometritis in women with repeated implantation failures (RIFs).
Materials and methods: Examinations were made in 84 women with chronic endometritis and RIFs who had been treated using in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) in the “PERSONA” International Clinical Center of Reproductology (Almaty, Kazakhstan) in January 2020 to January 2022 and followed up within 9 months after treatment. Two groups were identified by the treatment method: a study group that received antibacterial therapy in combination with bivhyaluronidase azoximer; a control group used antibacterial therapy alone.
Results: After treatment, a negative result to the expression of CD138+ cells was considerably frequent in the study group than in the control group (0.88±1.27 versus 6.48±7.40; p=0.00014). The pregnancy rate in the first cycle after transfer of a single frozen-thawed embryo was statistically higher in the study group than in the control group (78% versus 41.1%; р<0.001). Accordingly, the live birth rate was also higher in the study group than in the control group (62% versus 32.3%; р=0.008).
Conclusion: Chronic endometritis frequently occurs in women with RIFs. The results of the conducted study showed the high efficiency of using bovhyaluronidase azoximer in combination with antibacterial therapy, a substantial reduction in the expression of CD138+ cells, and increases in the rate of pregnancy, and the live birth rates in this category of women.
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About the authors
Vyacheslav N. Lokshin
“PERSONA” International Clinical Center of Reproductology
Email: v_lokshin@persona-ivf.kz
ORCID iD: 0000-0002-4792-5380
Academician of the National Academy of Sciences of the Republic of Kazakhstan, Professor, Chief Reproductive Specialist of the Ministry of Reproductive Medicine, President of the Kazakhstan Association of Reproductive Medicine, General Director of the “PERSONA” International Clinical Center of Reproductology
Kazakhstan, AlmatyYenglik Askar
“PERSONA” International Clinical Center of Reproductology; Asfendiyarov Kazakh National Medical University
Author for correspondence.
Email: yenglik.askar@yahoo.com
ORCID iD: 0000-0002-2538-3728
Obstetrician-Gynecologist, “PERSONA” International Clinical Center of Reproductology; Doctoral Student, Asfendiyarov Kazakh National Medical University
Kazakhstan, Almaty; AlmatyAnastasia N. Rybina
“PERSONA” International Clinical Center of Reproductology; Asfendiyarov Kazakh National Medical University
Email: oedema@mail.ru
ORCID iD: 0000-0002-9368-6683
Reproductive Specialist, Obstetrician-Gynecologist, “PERSONA” International Clinical Center of Reproductology, Doctoral Student, Asfendiyarov Kazakh National Medical University
Kazakhstan, Almaty; AlmatyAigerim T. Abshekenova
“PERSONA” International Clinical Center of Reproductology; Asfendiyarov Kazakh National Medical University
Email: abshekenova@gmail.com
ORCID iD: 0000-0002-3138-6650
Reproductive Specialist, Obstetrician-Gynecologist, “PERSONA” International Clinical Center of Reproductology; Doctoral Student, Asfendiyarov Kazakh National Medical University
Kazakhstan, Almaty; AlmatySholpan K. Karibayeva
“PERSONA” International Clinical Center of Reproductology; Asfendiyarov Kazakh National Medical University
Email: sh.karibaeva@gmail.com
ORCID iD: 0000-0001-5691-8652
PhD, Associate Professor of the Department of Obstetrics and Gynecology, Asfendiyarov Kazakh National Medical University; Reproductologist, Obstetrician-Gynecologist, Director of Strategic Development, “PERSONA” International Clinical Center of Reproductology
Kazakhstan, Almaty; AlmatyRavil K. Valiev
“PERSONA” International Clinical Center of Reproductology
Email: rvaliev75@mail.ru
ORCID iD: 0000-0003-2526-4291
PhD, Reproductive Specialist, Obstetrician-Gynecologist
Kazakhstan, AlmatyReferences
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