Impact of systemic menopausal hormone therapy on symptoms of urinary incontinence in postmenopausal women

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Abstract

Urinary incontinence (UI) is one of the common symptoms in postmenopausal women. There is estrogen deficiency at the heart of the development of this disorder, as well as other signs of genitourinary syndrome of menopause (GSM), which makes menopausal hormone therapy (MHT) pathogenetically justified.

The review includes the data of foreign and foreign publications found in the PubMed on this topic for the period from 2016 to 2022. The data available in the modern literature on the impact of systemic MHT on the symptoms of UI in postmenopausal women were systematically analyzed to improve approaches and to optimize patient management tactics.

Conclusion: Parodoxically, systemic MHT causes deterioration or development of UI, which may be associated with the effects of systemic estrogens on collagen metabolism in the perurethral tissues. Further study of the effect of estradiol-containing therapy on the genitourinary tract of postmenopausal women is relevant for the improvement of approaches and for the optimization of patient management tactics.

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About the authors

Diana S. Makovskaya

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Author for correspondence.
Email: md.makovskaya@gmail.com
ORCID iD: 0000-0003-0159-8641

obstetrician-gynecologist, Junior Researcher at the Department of Aesthetic Gynecology and Rehabilitation

Russian Federation, Moscow

Inna A. Apolikhina

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: apolikhina@inbox.ru
ORCID iD: 0000-0002-4581-6295

Dr. Med. Sci., Professor, Head of the Department of Aesthetic Gynecology and Rehabilitation

Russian Federation, Moscow

Elena A. Gorbunova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: el_gorbunova@oparina4.ru
ORCID iD: 0000-0002-4723-4299

obstetrician-gynecologist, Researcher at the Department of Aesthetic Gynecology and Rehabilitation

Russian Federation, Moscow

Svetlana V. Yureneva

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: syureneva@gmail.com
ORCID iD: 0000-0003-2864-066X

Dr. Med. Sci., Professor at the Department of Obstetrics and Gynecology of the Department of Vocational Education, Deputy Director of the Institute of Oncogynecology and Mammology

Russian Federation, Moscow

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