Platelet function and blood clotting during normal pregnancy

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Abstract

Objective: To investigate the changes in hemostasis during healthy pregnancy.

Materials and methods: Platelet contractile function assessed as a degree of blood clot contraction was studied in 38 healthy pregnant women, in relation to the markers of platelet activation, hemogram, hemostatic tests, and analysis of prothrombotic genetic polymorphisms.

Results: From the first week of normal pregnancy to delivery, there was moderate but statistically significant progressive impairment of blood clot contraction. A decrease in the ability of blood clots to shrink may be associated with physiological thrombocytopenia as well as partial continuous activation and exhaustion of platelets against a background of hypercoagulability and hyperfibrinogenemia. In 23/28 (82%) pregnant women, a transient reduction in the degree of clot contraction below the reference values was observed between 18 and 24 weeks of pregnancy. This reduction corresponds to the timing of placentation, suggesting local intraplacental mechanisms of platelet involvement during normal pregnancy.

Conclusion: The findings demonstrate the value of laboratory evaluation of platelet hemostasis, including platelet contractile function, during pregnancy.

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About the authors

Svetlana I. Safiullina

Institute of Fundamental Medicine and Biology, Kazan Federal University; Aibolit Medical Center

Author for correspondence.
Email: svetlana.ild.safiullina@gmail.com
ORCID iD: 0000-0003-4657-0140

M.D. Ph.D., Associate Professor

Russian Federation, Kazan; Kazan

Natalia G. Evtugina

Institute of Fundamental Medicine and Biology, Kazan Federal University

Email: natalja.evtugyna@gmail.com
ORCID iD: 0000-0002-4950-3691

PhD student

Russian Federation, Kazan

Alina D. Peshkova

Institute of Fundamental Medicine and Biology, Kazan Federal University

Email: alinapeshkova26@gmail.com
ORCID iD: 0000-0002-8790-1818

PhD, Senior Teacher

Russian Federation, Kazan

Rustem I. Litvinov

University of Pennsylvania School of Medicine

Email: rustempa@gmail.com
ORCID iD: 0000-0003-0643-1496

M.D., Ph.D., Dr. Sci., Senior Research Investigator

United States, Philadelphia, Pennsylvania

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