Comparative analysis of the effectiveness of programs and perinatal outcomes after frozen-thawed embryo transfer depending on post-transfer support medications
- Authors: Bashmakova N.V.1, Lokshin V.N.2, Isenova S.S.3, Khramtsova A.Y.1, Dankova I.V.1, Ryabukhin I.V.1
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Affiliations:
- Urals Scientific Research Institute for Maternal and Child Care, Ministry of Health of Russia
- PERSONA International Clinical Center for Reproductive Medicine
- Asfendiyarov Kazakh National Medical University
- Issue: No 7 (2023)
- Pages: 103-108
- Section: Original Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/568724
- DOI: https://doi.org/10.18565/aig.2023.161
- ID: 568724
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Abstract
Choosing the optimal protocol for preparing the endometrium for frozen-thawed embryo transfer is the most important issue of personalized selection of therapy for improving the effectiveness of assisted reproductive technology (ART) programs.
Objective: To evaluate the effectiveness of frozen-thawed embryo transfer programs and pregnancy outcomes depending on the type of progestogen used for secretory endometrial transformation and post-transfer support.
Materials and methods: The study included 334 infertile women who had frozen-thawed own embryo transfer with hormone replacement therapy cycle in the Assisted Reproduction Department, Urals Scientific Research Institute for Maternal and Child Care. The first group consisted of 224 patients who took dydrogesterone (30 mg/day orally) for full secretory transformation of the endometrium, the second group included 110 patients who were prescribed micronized vaginal progesterone (600 mg/day).
Results: The clinical pregnancy rate in group 1 was 86/224 (38.39%), and it was 38/110 (34.54%) in group 2; however, there was no statistical difference depending on the type of progestogen which was used to support the luteal phase (p=0.468). The term delivery rate in the group of women taking dydrogesterone was 42/86 (48.83%), and it was 14/38 (36.84%) in the comparison group (p=0.216). There was a tendency to a decrease in the preterm birth rate in group 1, namely, 6/86 (6.97%), while it was 6/38 (15.79%) in group 2 (p=0.126). There was no statistically significant difference in the rate of termination of pregnancy before 22 weeks in both groups (p=0.743): the rate of miscarriage in group 1 was 38/86 (44.18%), and it was 18/38 (47.36%) in group 2.
Conclusion: The data obtained in the study showed comparable effectiveness of progestogens in the clinical pregnancy rate and perinatal outcomes in the cycle of preparation for frozen-thawed embryo transfer. It is possible to use both micronized vaginal progesterone and dydrogesterone in cycles of hormone replacement therapy for preparing the endometrium for frozen-thawed embryo transfer.
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About the authors
Nadezda V. Bashmakova
Urals Scientific Research Institute for Maternal and Child Care, Ministry of Health of Russia
Author for correspondence.
Email: BashmakovaNV@niiomm.ru
SPIN-code: 9604-0089
Dr. Med. Sci., Professor, Honored Doctor of the Russian Federation, Head of department of ART, Chief obstetrician-gynecologist of the Ural Federal District, Chief Researcher
Russian Federation, 620028, Yekaterinburg, Repin str., 1Vyacheslav N. Lokshin
PERSONA International Clinical Center for Reproductive Medicine
Email: BashmakovaNV@niiomm.ru
Dr. Med. Sci., Professor, Academician of the National Academy of Sciences of the Republic of Kazakhstan, President of the Kazakhstan Association of Reproductive Medicine, Rector of the International Academy of Reproductology, President of the Association of International Pharmaceutical Manufacturers
Kazakhstan, Almaty, Utepova str., 32aSayle Sh. Isenova
Asfendiyarov Kazakh National Medical University
Email: isienova10@mail.ru
ORCID iD: 0000-0003-1869-746X
Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology
Kazakhstan, AlmatyAlexandra Yu. Khramtsova
Urals Scientific Research Institute for Maternal and Child Care, Ministry of Health of Russia
Email: BashmakovaNV@niiomm.ru
ORCID iD: 0000-0002-4304-3516
SPIN-code: 2467-5326
Scopus Author ID: 57214320389
PhD, obstetrician-gynecologist, researcher, Department of ART
Russian Federation, 620028, Yekaterinburg, Repin str., 1Irina V. Dankova
Urals Scientific Research Institute for Maternal and Child Care, Ministry of Health of Russia
Email: BashmakovaNV@niiomm.ru
ORCID iD: 0000-0002-7893-4722
PhD, Researcher at the Department of Women's Reproductive Function Preservation
Russian Federation, 620028, Yekaterinburg, Repin str., 1Igor V. Ryabukhin
Urals Scientific Research Institute for Maternal and Child Care, Ministry of Health of Russia
Email: BashmakovaNV@niiomm.ru
Senior Embryologist, Department of Assisted Reproductive Technologies
Russian Federation, 620028, Yekaterinburg, Repin str., 1References
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