BRCA-associated breast cancer during pregnancy

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Abstract

Background: Breast cancer (BC) is the most common breast form diagnosed during pregnancy (from 1:3,000 to 1:10,000 cases) and is about 3% of all forms of BC. Physiological changes during pregnancy can hide the early signs of BC and, thereby, delay the diagnosis. When planning treatment during pregnancy, in each case, it is inevitable to discuss the gestation period, stage and form of BC.

Case report: The paper describes a clinical case of a 28-year-old pregnant woman with malignant breast neoplasm diagnosed at 9.1 weeks’ gestation, with a family history, BRCA1 gene mutation, and HER2neи amplification. Due to the patient's refusal to terminate the pregnancy, resection of the left breast with a nodular mass and biopsy of the sentinel lymph node biopsy were performed. A postoperative histological examination confirmed high-grade invasive ductal carcinoma; no metastases were found in the distant lymph nodes. A consultation of doctors recommended adjuvant chemotherapy according to the AS regimen with an inter-cycle drug administration period of 21 days and subsequent targeted therapy with trastuzumab after delivery.

Conclusion: The discussed case reflects the complexities of diagnosis and combination treatment in pregnant patients with BC.

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About the authors

Lilia A. Bakhova

“Medical City” Multidisciplinary Clinical Medical Center; Tyumen State Medical University, Ministry of Health of Russia

Email: lilya8913@mail.ru
ORCID iD: 0000-0002-8918-6264
SPIN-code: 8832-3547

Senior Lecturer, Department of Oncology, Radiology and Radiotherapy, Institute of Clinical Medicine

Russian Federation, Tyumen; Tyumen

Tatiana P. Shevlyukova

Tyumen State Medical University, Ministry of Health of Russia

Email: tata21.01@mail.ru
ORCID iD: 0000-0002-7019-6630
SPIN-code: 5035-7233

Dr. Med. Sci., Professor, Department of Obstetrics and Gynecology, Institute of Maternity and Childhood

Russian Federation, Tyumen

Artem A. Keln

“Medical City” Multidisciplinary Clinical Medical Center; Tyumen State Medical University, Ministry of Health of Russia

Email: Artyom-keln@yandex.ru
ORCID iD: 0000-0002-5071-0604
SPIN-code: 9633-0276

PhD, Associate Professor, Department of Oncology, Radiology and Radiotherapy, Institute of Clinical Medicine

Russian Federation, Tyumen; Tyumen

Maxim S. Shvedsky

Tyumen State Medical University, Ministry of Health of Russia

Author for correspondence.
Email: Shvedsky99@gmail.com
ORCID iD: 0000-0002-8854-2773
SPIN-code: 2797-1965

6th-year student, Institute of Clinical Medicine

Russian Federation, Tyumen

Elena A. Mateykovich

Tyumen State Medical University, Ministry of Health of Russia

Email: mat-maxim@yandex.ru
ORCID iD: 0000-0002-2612-7339
SPIN-code: 5864-8031

PhD, Associate Professor, Department of Obstetrics and Gynecology, Director of the Institute of Maternity and Childhood

Russian Federation, Tyumen

Oksana V. Nekrasova

“Medical City” Multidisciplinary Clinical Medical Center

Email: kuban.ksu@mail.ru

Head of OPLT Department No. 2

Russian Federation, Tyumen

Vlada V. Shkuratova

“Medical City” Multidisciplinary Clinical Medical Center

Email: shkuratovavv@mail.ru

doctor, OPLT No. 2

Russian Federation, Tyumen

Olga S. Karmaeva

“Medical City” Multidisciplinary Clinical Medical Center

Email: oskormina@mail.ru

Head of the Department of Molecular Genetics and Oncochemistry, Pathology Bureau

Russian Federation, Tyumen

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