Experience of clinical application of the vapigel prebiotic in combined two-stage therapy of bacterial vaginosis in reproductive-aged women
- Authors: Belyakina I.V.1,2, Galkina I.S.3, Shobolov D.L.4, Shtykunova E.V.4, Arantseva D.A.4
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Affiliations:
- Pirogov National Medical and Surgical Center, Ministry of Health of Russia
- Kars Medical Center
- DNA-Technology LLC
- Kinetic-Pharm LLC
- Issue: No 11 (2023)
- Pages: 170-178
- Section: Exchange of Experience
- URL: https://journals.eco-vector.com/0300-9092/article/view/626138
- DOI: https://doi.org/10.18565/aig.2023.2371
- ID: 626138
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Abstract
Objective: To evaluate the clinical and laboratory parameters of women with bacterial vaginosis before and after two-stage therapy with prebiotic vaginal gel.
Materials and methods: Twenty patients with bacterial vaginosis aged 28–46 years (median 37±9) were examined and treated in two stages. Vapigel was prescribed at the second stage of treatment for bacterial vaginosis (after antibiotic therapy) at a dose of one tube once a day (before bedtime) for seven days intravaginally. Clinical and laboratory parameters were evaluated before treatment (Visit 0), on days 8+2 from the beginning of the course of treatment with Vapigel (Visit 1) and on days 30+2 after the end of the second stage of treatment (Visit 2).
Results: There was a positive dynamics of clinical symptoms immediately after the end of therapy (Visit 1) and after 30 days (Visit 2). After the patients received the two-stage therapy with Vapigel prebiotic, the frequency of detection of Lactobacillus spp. in the concentration of 106 CFU/ml increased to 60% by Visit 1 and to 90% by Visit 2. The proportion of patients with clinically significant amounts of facultative and obligate anaerobic microorganisms tended to decrease immediately after the end of two-stage treatment and a month later. During the month after the end of the course of therapy, there were no clinical signs of a recurrence of bacterial vaginosis in 19/20 (95%) women; normal flora was confirmed 30 days after the end of treatment in 18/20 (90%) women.
Conclusion: The use of the Vapigel prebiotic intravaginally is beneficial for restoring the microbiocenosis of the vaginal microflora at the second stage of therapy of bacterial vaginosis. It is necessary to study the possibility of using Vapigel as a monotherapy for bacterial vaginosis as an important component in the system of measures aimed at reducing the use of antimicrobial drugs in routine clinical practice.
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About the authors
Irina V. Belyakina
Pirogov National Medical and Surgical Center, Ministry of Health of Russia; Kars Medical Center
Author for correspondence.
Email: doctorbelyakina@mail.ru
Ph.D., gynecologist, obstetrician, Associate Professor at the Department of Women's Diseases and Reproductive Health of the Institute for Advanced Medical Studies
Russian Federation, 105203, Moscow, Nizhnyaya Pervomaiskaya str., 70; 127434, Moscow, Dmitrovskoye shosse, 21AIrina S. Galkina
DNA-Technology LLC
Email: Galkina@dna-technology.ru
Ph.D., Marketing Director
Russian Federation, 117587, Moscow, Varshavskoye sh., 125Zh, bldg. 6Dmitry L. Shobolov
Kinetic-Pharm LLC
Email: shobolov@kineticpharm.ru
ORCID iD: 0000-0002-2522-0582
Ph.D., General Director, Kinetiс-Pharm LLC
Russian Federation, 141560, Moscow Region, Solnechnogorsk, md. Dedeshino (village Alabushevo), 7Elena V. Shtykunova
Kinetic-Pharm LLC
Email: keen_272001@mail.ru
Ph.D., Medical Director
Russian Federation, 141560, Moscow Region, Solnechnogorsk, md. Dedeshino (village Alabushevo), 7Diana A. Arantseva
Kinetic-Pharm LLC
Email: arantseva@kineticpharm.ru
ORCID iD: 0000-0003-0920-6921
Head of the Laboratory of Parenteral Dosage Forms and Delivery Systems
Russian Federation, 141560, Moscow Region, Solnechnogorsk, md. Dedeshino (village Alabushevo), 7References
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