Non-hormonal treatment of women with genitourinary syndrome of menopause

Background: Vulvar and vaginal dryness accompanied by discomfort is a common problem among women. This problem occurs at various stages of life, including premenopausal, postpartum and postoperative periods. Although hormone therapy is the conventional approach, there is a need for effective and safe non-hormonal alternatives.

Objective: To evaluate the vaginal microbiome, as well as efficacy and safety of Xylalgin vaginal suppositories in women with symptoms of vaginal dryness and related discomfort.

Materials and methods: This was an observational study including 80 female patients who applied Xylalgin once daily in the vagina for 7–10 days. Microbiome was assessed by fluorescence in situ hybridization (FISH).

Results: The suppositories demonstrated a statistically significant reduction in vulvar and vaginal itching and dryness, and an increase in the Vaginal Health Index. The FISH data showed a tendency to normalization of the vaginal microbiome, which was expressed in a decrease in the number of opportunistic microorganisms and an increase in the proportion of lactobacilli that are characteristic of normocenosis. No adverse events associated with the use of suppositories were observed. The effect of the suppositories was rated as completely satisfactory by 84% of the patients.

Conclusion: Xylalgin is a promising non-hormonal treatment for relieving symptoms of vulvar and vaginal dryness and discomfort, helping to improve women’s quality of life. The study emphasizes the importance of finding safe and effective solutions for this common problem.