The severity of the climacteric syndrome and mobility impairments in women with musculoskeletal disorders and different types of menopause

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Relevance: With increasing life expectancy in developed countries, the incidence of age-related musculoskeletal disorders (MSDs) has increased in postmenoupausal women. There is a growing need for exploring new methods for early diagnosis of these conditions.

Objective: To explore the severity of the climacteric syndrome (CS) and mobility impairments in women aged 55–60 years with MSDs and with natural and surgical menopause.

Materials and methods: The study included 104 female patients aged 55–60 years with CS. They were divided into 2 groups; group 1 included 54 women with natural menopause, and group 2 included 50 women with surgical menopause. Assessment of the severity of CS and locomotive syndrome (LS), the state of bone tissue measured by using fragility score, bioimpedance analysis to evaluate muscle tissue status, hand grip dynamometry, and the sit-and-rise test (5 times with no hands) was conducted.

Results: It was found that the group of women with surgical menopause developed severe CS manifestations. The median score of the Greene climacteric scale in this group was 12 (6;19), that was significantly higher than in the group of women with natural menopause – 8.5 (6;17) (p=0.0177). The fragility score of the lumbar spine was lower in group 1 – 26.1 (24.7; 30.8) in comparison with group 2 – 31.1 (26.1; 33.2) (p=0.023). According to the "Locomo 25" questionnaire, the median in group 2 was significantly higher – 12.0 (8; 18) versus 9.6 (3.5; 12) in group 1 (p=0.017). It was found that LS stage 1 was more common in women with natural menopause, while LS stage 2 was associated with surgical menopause.

Conclusion: The obtained results indicate a high prevalence of mobility impairments and musculoskeletal diseases in 55–60 year old women with climacteric syndrome. Therefore, further large-scale multicenter studies are needed.

Full Text

Restricted Access

About the authors

Lilia A. Nosova

N.I. Pirogov Russian National Research Medical University (RNRMU), Ministry of Health of Russia

Email: karelina_lilia@mail.ru
ORCID iD: 0000-0002-0925-3755

Teaching Assistant at the Department of Obstetrics and Gynecology, Institute of Surgery

Russian Federation, 117997, Moscow, Ostrovityanov str., 1

Asiyat Z. Khashukoeva

Russian Gerontological Research and Clinical Center of the RNRMU, Ministry of Health of Russia; N.I. Pirogov Russian National Research Medical University (RNRMU), Ministry of Health of Russia

Author for correspondence.
Email: azk05@mail.ru
ORCID iD: 0000-0001-7591-6281

Dr. Med. Sci., Professor, Professor at the Department of Obstetrics and Gynecology, Institute of Surgery, obstetrician-gynecologist

Russian Federation, 117997, Moscow, Ostrovityanov str., 1; 129226, Moscow, 1st Leonova str., 16

Anton V. Naumov

Russian Gerontological Research and Clinical Center of the RNRMU, Ministry of Health of Russia; N.I. Pirogov Russian National Research Medical University (RNRMU), Ministry of Health of Russia

Email: nanton@mail.ru
ORCID iD: 0000-0002-6253-621X

Dr. Med. Sci., Professor at the Department of Diseases of Aging, Faculty of Additional Professional Education, Head of the Laboratory of Diseases of the Musculoskeletal System

Russian Federation, 117997, Moscow, Ostrovityanov str., 1; 129226, Moscow, 1st Leonova str., 16

Anna M. Soloveva

N.I. Pirogov Russian National Research Medical University (RNRMU), Ministry of Health of Russia

Email: annasol02@yandex.ru
ORCID iD: 0009-0006-9569-5045

student

Russian Federation, 117997, Moscow, Ostrovityanov str., 1

Yulia A. Smagina

N.I. Pirogov Russian National Research Medical University (RNRMU), Ministry of Health of Russia

Email: yulia-smagina709@mail.ru
ORCID iD: 0009-0009-3893-4988

student

Russian Federation, 117997, Moscow, Ostrovityanov str., 1

References

  1. Сулима А.Н., Булюк В.В., Митрофанова О.А. Постменопаузальный остеопороз. Акушерство и гинекология. 2023; 9: 52-59. [Sulima A.N., Bulyuk V.V., Mitrofanova O.A. Postmenopausal osteoporosis. Obstetrics and Gynecology. 2023; (9): 52-9. (in Russian)]. https://dx.doi.org/10.18565/aig.2023.103.
  2. Хашукоева А.З., Кузнецова О.В., Оверко А.В., Дмитрашко Т.Е. Как жить пожилой женщине с выпадением половых органов? Лечащий Врач. 2021; 12(24): 10-6. [Khashukoeva A.Z., Kuznetsova O.V., Overko A.V., Dmitrashko I.E. How to live an elderly woman with prolapse of the genitals? Lechaschy Vrach Journal. 2021; 12(24): 10-6. (in Russian)]. https:// dx.doi.org/10.51793/OS.2021.24.12.001.
  3. Jin Z., Tian C., Kang M., Hu S., Zhao L., Zhang W. The 100 top-cited articles in menopausal syndrome: a bibliometric analysis. Reprod. Health. 2024; 21(1): 47. https://dx.doi.org/10.1186/s12978-024-01770-9.
  4. Усова Н.Н., Ходькова Ю.В. Особенности развития болевых синдромов в пожилом возрасте. Медицинские новости. 2022; 2: 24-7. [Usava N.N., Khodkova Yu.V. Features of the development of pain syndromes in old age. Medical News. 2022; 2: 24-7. (in Russian)].
  5. Di Martino A., Barile F., D'Agostino C., Castafaro V., Cerasoli T., Mora P. et al. Are there gender-specific differences in hip and knee cartilage composition and degeneration? A systematic literature review. Eur. J. Orthop. Surg. Traumatol. 2024; 34(4): 1901-10. https://dx.doi.org/10.1007/s00590-024-03871-4.
  6. Брюхина Е.В., Усольцева Е.Н., Иванова О.В. Качество жизни женщин в зависимости от проявлений климактерического синдрома. Акушерство и гинекология. 2014; 10: 52-8. [Bryukhina E.V., Usoltseva E.N., Ivanova O.V. The quality of life in women according to climacteric syndrome. Obstetrics and Gynecology. 2014; (10): 52-8. (in Russian)].
  7. Умарова Н.М., Абдикулова Н.Х., Нигматова Г.М. Остеопороз у женщин в перименопаузе. Пути диагностики, коррекции и профилактики (обзор литературы). Журнал репродуктивного здоровья и уро-нефрологических исследований. 2024; 5(1): 5-8. [Umarova N.M., Abdikulova N.Kh., Nigmatova G.M. Osteoporosis in perimenopausal women. Diagnostic, correction and prevention pathways (literature review). Journal of Reproductive Health and Uro-Nephrological Research. 2024; 5(1): 5-8. (in Russian)]. https://dx.doi.org/10.5281/zenodo.10909224.
  8. Tomida M., Otsuka R., Tange C., Nishita Y., Kimura T., Stoelzel M. et al. Vasomotor symptoms, sleep problems, and depressive symptoms in community-dwelling Japanese women. J. Obstet. Gynaecol. Res. 2021; 47(10): 3677-90. https://dx.doi.org/10.1111/jog.14937.
  9. Pillay O.C., Manyonda I. The surgical menopause. Best Pract. Res. Clin. Obstet. Gynaecol. 2022; 81: 111-8. https://dx.doi.org/10.1016/j.bpobgyn.2022.03.001.
  10. Ozdemir S., Celik C., Görkemli H., Kiyici A., Kaya B. Compared effects of surgical and natural menopause on climacteric symptoms, osteoporosis, and metabolic syndrome. Int. J. Gynaecol. Obstet. 2009; 106(1): 57-61. https://dx.doi.org/10.1016/j.ijgo.2009.03.016.
  11. Коротких И.Н., Савельева Н.В., Боржи У.М. Основные проблемы естественной и хирургической менопаузы. Научно-медицинский вестник Центрального Черноземья. 2006; 26: 85-9. [Korotkikh I.N., Savelyeva N.V., Borzhi U.M. Main problems of natural and surgical menopause. Medical Scientific Bulletin of Central Chernozemye. 2006; 26: 85-9. (in Russian)]. https://dx.doi.org/10.18499/1990-472X-2006-0-26-85-89.
  12. Vallejo M.S., Blümel J.E., Chedraui P., Tserotas K., Salinas C., Rodrigues M.A. et al. Association of muscle disorders in late postmenopausal women according to the type of experienced menopause. Menopause. 2024; 31(7): 641-6. https://dx.doi.org/10.1097/GME.0000000000002367.
  13. Huang G., Coviello A., LaValley M.P., Ensrud K.E., Cauley J.A., Cawthon P.M. et al. Surgical menopause and frailty risk in community-dwelling older women: study of osteoporotic fractures. J. Am. Geriatr. Soc. 2018; 66(11): 2172-7. https://dx.doi.org/10.1111/jgs.15505.
  14. Veronese N., Ragusa F.S., Sabico S., Dominguez L.J., Barbagallo M., Duque G. et al. Osteosarcopenia increases the risk of mortality: a systematic review and meta-analysis of prospective observational studies. Aging Clin. Exp. Res. 2024; 36(1): 132. https://dx.doi.org/10.1007/s40520-024-02785-9.
  15. Nakamura K. A "super-aged" society and the "locomotive syndrome". J. Orthop. Sci. 2008; 13(1): 1-2. https://dx.doi.org/10.1007/s00776-007-1202-6.
  16. Nakamura K., Ogata T. Locomotive syndrome: definition and management. Clin. Rev. Bone Miner. Metab. 2016; 14(2): 56-67. https://dx.doi.org/10.1007/s12018-016-9208-2.
  17. Shibata S., Kon S. Functional ingredients associated with the prevention and suppression of locomotive syndrome: a review. Biol. Pharm. Bull. 2024; 47(12): 1978-91. https://dx.doi.org/10.1248/bpb.b24-00443.
  18. Sawaya Y., Hirose T., Onuma S., Nakajima R., Fujita S., Muroi S. et al. Prevalence and associated factors of locomotive syndrome in young Japanese adults: a cross-sectional study. BMC Musculoskelet. Disord. 2024; 25(1): 366. https://dx.doi.org/10.1186/s12891-024-07493-z.
  19. Тополянская С.В., Романова М.А., Вакуленко О.Н., Бубман Л.И., Елисеева Т.А., Ларина Д.С., Рачина С.А., Дворецкий Л.И. «Локомотивный синдром» в практике гериатрического стационара. Медицинский алфавит. 2023; 13: 36-41. [Topolyanskaya S.V., Romanova M.A., Vakulenko O.N., Bubman L.I., Eliseeva T.A., Larina D.S., Ratchina S.A., Dvoretski L.I. «Locomotive syndrome» in patients in the geriatric hospital. Medical Alphabet. 2023; (13): 36-41. (in Russian)]. https://dx.doi.org/10.33667/10.33667/ 2078-5631-2023-13-36-41.
  20. Ikemoto T., Arai Y.C. Locomotive syndrome: clinical perspectives. Clin. Interv. Aging. 2018; 13: 819-27. https://dx.doi.org/10.2147/CIA.S148683.
  21. Ota K. Clinical anti-aging medicine: Anti-aging medicine for female reproductive organs. In: Yamada H., Yuji N., eds. Anti-aging medicine. Basics and clinical practice. Springer; 2025: 325-9. https://dx.doi.org/10.1007/ 978-981-97-8514-8_81.
  22. Якушевская О.В., Юренева С.В., Комедина В.И. Па-де-де остеопороза и саркопении: остеосаркопения. Медицинский совет. 2022; 6: 116-21. [Yakushevskaya O.V., Yureneva S.V., Komedina V.I. A pas de deux of osteoporosis and sarcopenia: osteosarcopenia. Medical Council. 2022; (6): 116-21. (in Russian)]. https://dx.doi.org/10.21518/2079-701X-2022-16-6-116-121.
  23. Greene J.G. Constructing a standard climacteric scale. Maturitas. 2008; 61(1-2): 78-84. https://dx.doi.org/10.1016/j.maturitas.2008.09.011.
  24. Sourouni M., Zangger M., Honermann L., Foth D., Stute P. Assessment of the climacteric syndrome: a narrative review. Arch. Gynecol. Obstet. 2021; 304(4): 855-62. https://dx.doi.org/10.1007/s00404-021-06139-y.
  25. Osawa Y., An Y., Nishita Y., Matsui Y., Takemura M., Simonsick E.M. et al. Longitudinal association between muscle and bone loss: Results of US and Japanese cohort studies. J. Cachexia Sarcopenia Muscle. 2024; 15(2): 746-55. https://dx.doi.org/10.1002/jcsm.13438.
  26. Торопцова Н.В. Взаимосвязь остеопороза и остеоартроза. Лечащий врач. 2006; 2: 38-42. [Toroptsova N.V. Relationship between osteoporosis and osteoarthritis. Lechaschi Vrach Journal. 2006; (2): 38-42. (in Russian)].
  27. Campodónico I., Blümel J.E., Arteaga E., Vallejo M.S., Valdivia M.I. Low bone mineral density in middle-aged women: a red flag for sarcopenia. Menopause. 2018; 25(3): 324-8. https://dx.doi.org/10.1097/GME.0000000000000995.
  28. Sriramaneni N., Selvan C., Kumar S.N., Kalra P., P G.Y., R M.P. et al. Quality of life in postmenopausal women and its association with sarcopenia. Menopause. 2024; 31(8): 679-85. https://dx.doi.org/10.1097/GME.0000000000002378.
  29. Sipilä S., Törmäkangas T., Sillanpää E., Aukee P., Kujala U.M., Kovanen V. et al. Muscle and bone mass in middle-aged women: role of menopausal status and physical activity. Journal of Cachexia, Sarcopenia and Muscle. 2020; 11(3): 698-709. https://dx.doi.org/10.1002/jcsm.12547.
  30. Кузнецов С.Ю. Клинические аспекты женского здоровья: половые стероиды и костная ткань. Остеопороз и остеопатии. 2022; 25(3): 72-3. [Kuznetsov S.Yu. Clinical aspects of women's health: sex steroids and bone tissue. Osteoporosis and Bone Diseases. 2022; 25(3): 72-3. (in Russian)]. https://dx.doi.org/10.14341/osteo13041.
  31. Blumer J. Arthralgia of menopause - A retrospective review. Post Reprod. Health. 2023; 29(2): 95-7. https://dx.doi.org/10.1177/20533691231172565.
  32. Wright V.J., Schwartzman J.D., Itinoche R., Wittstein J. The musculoskeletal syndrome of menopause. Climacteric. 2024; 27(5): 466-72. https://dx.doi.org/ 10.1080/13697137.2024.2380363.
  33. Wluka A.E., Davis S.R., Bailey M., Stuckey S.L., Cicuttini F.M. Users of oestrogen replacement therapy have more knee cartilage than non-users. Ann. Rheum. Dis. 2001; 60: 332-6. https://dx.doi.org/10.1136/ard.60.4.332.
  34. Cirillo D.J., Wallace R.B., Wu L., Yood R.A. Effect of hormone therapy on risk of hip and knee joint replacement in the Women's Health Initiative. Arthritis. Rheum. 2006; 54(10): 3194-204. https://dx.doi.org/10.1002/art.22138.
  35. Колбасова Е.А., Киселева Н.И., Арестова И.М. Сравнительная клинико-гормональная характеристика состояния здоровья и качество жизни женщин с хирургической и естественной менопаузой. Вестник Витебского государственного медицинского университета. 2014; 13(2): 78-86. [Kolbasova E.A., Kiseleva N.I., Arestova I.M. Comparative clinical and hormonal characteristics of the state of health and quality of life of women with surgical and natural menopause. Bulletin of Vitebsk State Medical University. 2014; 13(2): 78-86. (in Russian)].

Supplementary files

Supplementary Files
Action
1. JATS XML
Download
2. Fig. 1. Comparative characteristics of the severity of CS in groups at the time of examination

Download (53KB)
Indexing metadata
3. Fig. 2. Results of the Lokomo-25 questionnaire

Download (56KB)
Indexing metadata
4. Рис. 3. Результаты теста «Встань и иди»

Download (54KB)
Indexing metadata

Copyright (c) 2025 Bionika Media