The role of the components of the immune system in preterm birth due to placental dysfunction

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Objective: To evaluate the role of the components of the immune system in the pathogenesis of preterm birth due to severe preeclampsia and placental abruption of normally implanted placenta.

Materials and methods: A total of 80 women with induced preterm birth (the main group) were examined. The sample was divided into two subgroups. Subgroup 1 consisted of patients with abdominal delivery due to progression of severe preeclampsia. Subgroup 2 consisted of patients with preterm birth due to placental abruption of normally implanted placenta. The control group consisted of women with term uncomplicated birth. The levels of interleukin (IL)-8, IL-10, tumor necrosis factor alpha (TNF-α), human chorionic gonadotropin and pregnancy-associated plasma protein A (PAPP-A) were studied as the predictors of preterm birth.

Results: It was found that IL-8, TNF-α and PAPP-A play an important role in the pathogenesis of induced preterm birth due to severe obstetric complications. Elevation of IL-8 level by 1 unit increases the risk of preterm birth by 2.96 times; elevation of TNF-α level by 1 unit increases the risk of preterm birth by 1.56 times, while elevation of PAPP-A level by 1 unit reduces the risk of adverse outcomes by 0.04 times.

Conclusion: The components of the immune system play an important role in the pathogenesis of preterm birth and placental dysfunction. Research in this area expands knowledge of the mechanisms of severe obstetric complications and is important for prediction of adverse obstetric outcomes.

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Sobre autores

Anna Nikolaeva

Semey Medical University

Email: avealokinanna@mail.ru
ORCID ID: 0000-0002-2642-5141

Researcher at the A.A. Kozbagarov Department of Obstetrics and Gynecology

Cazaquistão, 071400, Semey, Abay str., 103

Gulyash Tanysheva

Semey Medical University

Email: gulyash1965@mail.ru
ORCID ID: 0000-0001-9531-5950

PhD, Associate Professor, Head of the A.A. Kozbagarov Department of Obstetrics and Gynecology

Cazaquistão, 071400, Semey, Abay str., 103

Olga Koliado

Altai State Medical University, Ministry of Health of Russia

Email: olga.kolyado@yandex.ru
ORCID ID: 0000-0002-5812-4925

PhD, Teaching Assistant at the Department of Obstetrics, Gynecology with course of additional professional education

Rússia, 656038, Barnaul, Lenin str., 40

Olga Remneva

Altai State Medical University, Ministry of Health of Russia

Autor responsável pela correspondência
Email: rolmed@yandex.ru
ORCID ID: 0000-0002-5984-1109

Dr. Med. Sci., Professor, Head of the Department of Obstetrics, Gynecology with course of additional professional education

Rússia, 656038, Barnaul, Lenin str., 40

Irina Molchanova

Altai State Medical University, Ministry of Health of Russia

Email: molcanova2008@yandex.ru
ORCID ID: 0000-0002-0741-8974

PhD, Associate Professor at the Department of Obstetrics, Gynecology with course of additional professional education

Rússia, 656038, Barnaul, Lenin str., 40

Altay Dyusupov

Semey Medical University

Email: altay.dyusupov@smu.edu.kz
ORCID ID: 0000-0003-0875-1020

Dr. Med. Sci., Professor, Rector

Cazaquistão, 071400, Semey, Abay str., 103

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