Cytogenetic examination of the married couples included into assisted reproductive technology programs

Zhanna Ivanovna Glinkina; Глинкина Жанна Ивановна; L N Kuz'michev; Кузьмичев Л Н; V V Mamonova; Мамонова В В; T V Bugay; Бугай Т В; G D Azizova; Азизова Г Д; V G Mikaelyan; Микаелян В Г; M V Ikonnikov; Иконников М В; N V Romanova; Романова Н В; O E Lebedeva; Лебедева О Е; Zh I Glinkina; Glinkina Zh I; L N Kuzmichev; Kuzmichev L N; V V Mamonova; Mamonova V V; T V Bugai; Bugai T V; G D Azizova; Azizova G D; V G Mikayelyan; Mikayelyan V G; M V Ikonnikov; Ikonnikov M V; N V Romanova; Romanova N V; O Ye Lebedeva; Lebedeva O Ye

Cytogenetic examination of the married couples included into assisted reproductive technology programs

Authors: Glinkina Z.I.¹, Kuz'michev LN¹, Mamonova VV¹, Bugay TV¹, Azizova GD¹, Mikaelyan VG¹, Ikonnikov MV¹, Romanova NV¹, Lebedeva OE¹, Glinkina Z.I², Kuzmichev LN², Mamonova VV², Bugai TV², Azizova GD², Mikayelyan VG², Ikonnikov MV³, Romanova NV², Lebedeva OY.²
Affiliations:
2. Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow
3. Molecular Diagnostic Subdivision, ZAO Roche-Moscow
Issue: No 3 (2010)
Pages: 39-42
Section: Articles
URL: https://journals.eco-vector.com/0300-9092/article/view/246349
ID: 246349

Cite item

Abstract

The study has indicated that the incidence of chromosomal abnormalities among the patients included into assisted reproduction technology (ART) programs is 3%. This implies that 6% of the married couples have a high risk of having a baby with genetic pathology. Changes in the complex of sex chromosomes were presented in 54.1% of cases. Of them, 63% of cases showed gonosomal mosaicism. Chromosomal translocations were the second most common conditions. Robertsonian and reciprocal translocations were encountered in the same percentage of cases. Moreover, Robertsonian translocation with involvement of chromosomes 13 and 14 was found in 81.25% of cases. Knowledge of the patients having chromosomal changes will help to beforehand make required correction of treatment and, thus, to facilitate the higher effectiveness of IVF programs and the prevention of having a baby with genetic abnormalities within the framework of an ART program.

Keywords

reproductive function, cytogenetic study, karyotype, in vitro fertilization

References

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Cytogenetic examination of the married couples included into assisted reproductive technology programs

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