Cytogenetic examination of the married couples included into assisted reproductive technology programs


Дәйексөз келтіру

Толық мәтін

Аннотация

The study has indicated that the incidence of chromosomal abnormalities among the patients included into assisted reproduction technology (ART) programs is 3%. This implies that 6% of the married couples have a high risk of having a baby with genetic pathology. Changes in the complex of sex chromosomes were presented in 54.1% of cases. Of them, 63% of cases showed gonosomal mosaicism. Chromosomal translocations were the second most common conditions. Robertsonian and reciprocal translocations were encountered in the same percentage of cases. Moreover, Robertsonian translocation with involvement of chromosomes 13 and 14 was found in 81.25% of cases. Knowledge of the patients having chromosomal changes will help to beforehand make required correction of treatment and, thus, to facilitate the higher effectiveness of IVF programs and the prevention of having a baby with genetic abnormalities within the framework of an ART program.

Авторлар туралы

Zhanna Glinkina

Email: janna435@yandex.ru

L Kuz'michev

V Mamonova

T Bugay

G Azizova

V Mikaelyan

M Ikonnikov

N Romanova

O Lebedeva

Zh Glinkina

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

L Kuzmichev

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

V Mamonova

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

T Bugai

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

G Azizova

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

V Mikayelyan

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

M Ikonnikov

Molecular Diagnostic Subdivision, ZAO Roche-Moscow

Molecular Diagnostic Subdivision, ZAO Roche-Moscow

N Romanova

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

O Lebedeva

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Әдебиет тізімі

  1. Ворсанова С. Г., Юров Ю. Б., Соловьев И. В. Современные достижения молекулярной цитогенетики в диагностике хромосомной патологии у детей // Рос. вестн. перинатол. и педиатр. - 1998. - Т. 43, № 1. - С. 31-36.
  2. Кулешов Н. П. Частота возникновения и судьба хромосомных аномалий в популяции человека: Автореф. дис. ... д-ра мед. наук. - М., 1979.
  3. Курило Л. Ф., Дубинская В. П., Остроумова Т. В. и др. Анализ патологии сперматогенеза различной этиологии по эякуляту // Пробл. репрод. - 1995. - № 3. - С. 33-38.
  4. Курило Л. Ф. Частота и структура хромосомных аберраций у пациентов с репродуктивной недостаточностью // Мед. генетика. - 2007. - Т. 6, № 10 (64). - С. 41-44.
  5. Савельева А. П. Структура хромосомной патологии среди пациентов с мужским бесплодием и патозооспермией: Автореф. дис. ... канд. биол. наук. - М., 2002.
  6. Azim M., Khan A. H., Khilji Z. L. et al. Chromosomal abnormalities as a cause of recurrent abortions: a hospital experience // J. Pak. Med. Assoc. - 2003. - Vol. 53, N 3. - P. 117- 119.
  7. Causio F., Fischetto R., Schonauer L. M. et al. Intracytoplasmic sperm injection in infertile patients with structural cytogenetic abnormalities // J. Reprod. Med. - 1999. - Vol. 44, N 10. - P. 859-864.
  8. Jacobs P. A., Melville M., Ratcliffe S. et al. Cytogenetic survey of 11,680 newborn infants // Ann. Hum. Genet. - 1974. - Vol. 37, N 4. - P. 359-376.
  9. Meschede D., Lemcke B., Exeler J. R. et al. Chromosome abnormalities in 447 couples undergoing intracytoplasmic sperm injection - prevalence, types, sex distribution and reproductive relevance // Hum. Reprod. - 1998. - Vol. 13, N 3. - P. 576-582.
  10. Nielsen J., Wohlert M. Chromosome abnormalities among 34 910 newborn children: results from a 13-year incidence study in Arthus, Denmark // Hum. Genet. - 1991. - Vol. 87, N 1. - P. 81-83.
  11. Schreurs A., Legius E., Meuleman C. et al. Increased frequency of chromosomal abnormalities in female partners of couples undergoing in vitro fertilization or intracytoplasmic sperm injection // Fertil. and Steril. - 2000. - Vol. 74, N 7. - P. 94-99.
  12. Shirley G., Tierney S., Ushaho J. The Edinburgh study of growth and development of children with sex chromosome abnormalities // Birth Defects: Orig. Article Ser. - 1982. - Vol. 18, N 4. - P. 41-60.
  13. Stern C., PertileM., Norris H. et al. Chromosome translocation in couples with in vitro fertilization implantation failure // Hum. Reprod. - 1999. - Vol. 14, N 8. - P. 2097-2101.
  14. Testart J., Gautier E., Brami C. et al. Intracytoplamic sperm injection in infertile patients with structural chromosome abnormalities // Hum. Reprod. - 1996. - Vol. 11, N 12. - P. 2609-2612.
  15. Thompson M. Genetics in Medicine. - Philadelphia, 1991. - P. 47-52.
  16. Van Der Ven C., Peschka B., Montag M. et al. Increased frequency of congenital chromosomal aberrations in female partners of couples undergoing intracytoplasmic sperm injection // Hum. Reprod. - 1998. - Vol. 13, N 1. - P. 48-54.

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