Association of FBLN5 gene polymorphism with a risk for pelvic organ prolapse in women with soft tissue injuries in the generative passage


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Abstract

Objective. To search for polymorphic FBLN5 gene variants associated with a risk for POP in women. Subjects and methods. The investigation enrolled 502 women, including 210 patients diagnosed with grade 2-4 POP (POP-Q) and 292 without prolapse. Results and discussion. The minor alleles rs12586948-A, rs2018736-С, and rs2474028-Т were more frequently found in the women with POP than in the control group. The minor allele rs12589592-A was more common in the healthy women. The haplotype consisting of the risky alleles rs12586948(A) - rs2018736(C) - rs12589592(G) - rs2474028(T) with a frequency of 16.12% was characterized by the importance of its effect: P=0.0079, OR=3.51, 95% CI, 1.40-8.78. Conclusion. The genetic status detected by carriage of the found risky and protective alleles in the FBLN5 gene permits the risk of POP to be diagnosed in women with a history of soft tissue injuries in the generative passage.

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About the authors

Oleg V. Makarov

N.I. Pirogov Russian National Research Medical University

Email: profmakarov@mail.ru
MD, professor, head of Obstetrics and Gynecology Department One, Faculty of Therapeutics

Svetlana V. Kamoeva

N.I. Pirogov Russian National Research Medical University

Email: sv02016@yandex.ru
PhD, docent of Obstetrics and Gynecology Department One, Faculty of Therapeutics

Mariam B. Khadzhieva

N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences

Email: m.had@mail.ru
postgraduate student, Junior Researcher, Laboratory of Ecological Genetics

Anastasia V. Ivanova

N.I. Pirogov Russian National Research Medical University

Email: doc.av.ivanova@gmail.com
postgraduate student, Obstetrics and Gynecology Department One, Faculty of Therapeutics

Anastasia G. Chumachenko

N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences

Email: a_chumachenko@mail.ru
PhD, Researcher, Laboratory of Ecological Genetics

Serikbay K. Abilev

N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences

Email: serikbai@mail.ru
MD, professor Deputy Director for Science

Lyubov E. Salnikova

N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences

Email: salnikova@vigg.ru
MD, Leading Researcher, Laboratory of Ecological Genetics Chief Researcher

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