Invasive mycoses in neonatology: Prevention, diagnosis, and therapy


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Abstract

Objective. To study current approaches to the diagnosis, therapy, and prevention of invasive mycoses in neonates on the basis of the data available in the literature and the results of the authors’ investigations. Subject and methods. Current microbiological and proteometric techniques (time-of-flight MALD-TOF-MS) were used to study the species composition of fungi obtained when testing 391 biological samples from 187 babies treated at the Research Center of Obstetrics, Gynecology, and Perinatology in 2013-2014 and to estimate the isolation rates of yeast fungi in different neonatal departments. Results. Analysis of the data available in the literature and the results of the authors’ investigations could identify risk factors for the development of a fungal process in neonatal infants, determine indications for targeted antifungal therapy, and describe a group of drugs used for the therapy and prevention of invasive candidiasis in the neonatal period. Conclusion. Current diagnosis, early initiation of antifungal therapy, and observance of preventive measures will reduce the incidence of invasive candidiasis in the group of very low and extremely low birth weight neonates, increase survival rates, and decrease the pharmacoeconomic costs of their treatment.

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About the authors

Irina V. Nikitina

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: i_nikitina@oparina4.ru
Ph.D., doctor of the intensive care department of neonatology and pediatrics

Oleg V. Ionov

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: o_ionov@oparina4.ru
Ph.D Head of the intensive care department of neonatology and pediatrics

Natalya A. Prikhodko

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: n_prikhodko@oparina4.ru
junior researcher of the intensive care department of neonatology and pediatrics

Tatiana V. Priputnevich

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: priput1@rambler.ru
M.D., Ph.D Head of the department of microbiology and clinical pharmacology

Albert G. Antonov

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_antonov@oparina4.ru
MD, PhD, Professor, chief researcher of the intensive care department of neonatology and pediatrics

Lyudmila A. Lyubasovskaya

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: labmik@yandex.ru
Ph.D., clinical pharmacologist of the department of microbiology and clinical pharmacology

Anna R. Kirtbaya

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: kar13@mail.ru
MD, PhD, chief of clinician of the neonatal intensive care department

Ekaterina N. Balashova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: katbal99@gmail.com
MD, PhD, chief of clinician of the neonatal intensive care department

Victor V. Zubkov

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: victor.zubkov@mail.ru
MD, PhD Head of department of neonatology and pediatrics

Dmitry N. Degtyarev

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: d_degtyarev@oparina4.ru
MD, PhD, Professor, Deputy Director on scientific work

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