Prognostic value in determining the maternal autoantibodies during pregravid preparation, which affect the development of autism spectrum disorder in a baby


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Objective. To evaluate the diagnostic and prognostic capabilities of analyzing the profiles of serum immunoreactivity defined by a number of autoantibodies for the identification of women at risk of having a baby with autism spectrum disorder (ASD). Material and methods. The enzyme immunoassays ELI-Viscero-Test and ELI-Neuro-Test were used to investigate serum from mothers given birth to ASD babies and healthy ones. Results. The paper describes the most common disorders and complications occurring in the group of women who have given birth to a baby with ASD (a compromised somatic and obstetric/gynecological history), as well as their characteristic changes in the profiles of serum immunoreactivity. It discusses whether there may be a relationship between maternal immunoregulatory disorders and fetal malformations. Conclusion. The modified production of some maternal IgG autoantibodies that are tropic to antigens of the nervous system and to those of a number of somatic organs (detected by ELI-Viscero-Test and ELI-Neuro-Test) may be a decisive pathogenic factor leading to ASD in her baby.

Full Text

Restricted Access

About the authors

Amirhan M. Torchinov

A.I. Evdokimov Moscow State University of Medicine and Dentistry

Email: antonina.zanilova@gmail.com
MD, professor, Head of the Department of obstetrics and gynecology, stomatological faculty

Svetlana G. Tsakhilova

A.I. Evdokimov Moscow State University of Medicine and Dentistry

Email: dzh2010@mail.ru
MD, professor, Department of obstetrics and gynecology, stomatological faculty

Vadim P. Kuznetsov

Branch, City Clinical Hospital Sixty-Eight; A.I. Evdokimov Moscow State University of Medicine and Dentistry

Email: rd8@68gkb.ru
MD, Deputy chief physician for medical part of the Maternity Home Eight; Department of obstetrics and gynecology, stomatological faculty

Antonina V. Khmelnitskaya

Branch, City Clinical Hospital Sixty-Eight; A.I. Evdokimov Moscow State University of Medicine and Dentistry

Email: antonina.zanilova@gmail.com
Obstetrician-gynecologist, a Maternity Home Eight; Department of obstetrics and gynecology, stomatological faculty

Alexandr B. Poletaev

Immunkulus Medical Research Center; P.K. Anokhin Research Institute of Normal Physiology

Email: a-b-poletaev@yandex.ru
MD, professor, Scientific Director

References

  1. Сухих Г.Т., Ванько Л.В. Иммунология беременности. М.: РАМН; 2003. 376 с. [Sukhikh G.T., Vanko L.V. Immunology of pregnancy. Moscow: Russian Academy of Medical Sciences; 2003. 376p. (in Russian)]
  2. Хаитов Р.М. Иммунология. М.: ГЭОТАР-Медиа; 2011. 432с. [Khaitov R.M. Immunology. Moscow: GEOTAR-Media; 2011. 432p. (in Russian)]
  3. Подзолкова Н.М., Созаева Л.Г., Кошель Е.Н., Данилов А.Н., Полетаев А.Б. Папилломавирусная инфекция как фактор репродуктивного риска. Проблемы репродукции. 2008; 1: 24-9. [Podzolkova N.M., Sozayeva L.G., Koshel E.N., Danilov A.N., Poletaev A.B. Human Papillomavirus infection as a factor of reproductive risk. Problemy reproduktsii. 2008; 1: 24-9. (in Russian)]
  4. Чурилов Л.П., Васильев А.Г. Патофизиология иммунной системы. СПб.: «Издательство ФОЛИАНТ»; 2014. 644с. [Churilov L.P., Vasilyev A G. Pathophysiology of the immune system. St. Petersburg: “Izdatel’stvo FOLIANT”; 2014. 644p. (in Russian)]
  5. Полетаев А.Б., Алиева Ф. Аутоантитела и иммунопатология беременности. Практическая медицина. 2010; 4: 20-4. [Poletaev A.B. Autoantibodies and immunopathology of pregnancy. Prakticheskaya meditsina. 2010; 4: 20-24. (in Russian)]
  6. Сухих Г.Т., Матвеева Н.К. Показатели иммунитета у больных с папилломавирусной инфекцией гениталий. Акушерство и гинекология. 2000; 2: 43-6. [Sukhikh G.T., Matveev N.K. Indicators of immunity in patients with HPV infection of the genitals. Akusherstvo i ginekologiya/Obstetrics and gynecology. 2000; (2): 43-6. (in Russian)]
  7. Запорожан В.Н., Хаят О.В., Низова Н.Н. Изменения показателей иммунной и протеазно-ингибиторной систем при физиологической беременности. Акушерство и гинекология. 1992; 8: 8-11. [Zaporozhan V.N., Hayat O.V., Nizova N.N. Changes in the indices of immune and protease-inhibitor systems in normal pregnancy. Akusherstvo i ginekologiya/Obstetrics and gynecology. 1992; (8): 8-11. (in Russian)]
  8. Newschaffer C.J., Croen L.A., Daniels J., Giarelli E., Grether J.K., Levy S.E. et al. The epidemiology of autism spectrum disorders. Ann. Rev. Public Health. 2007; 28: 235-58.
  9. Безгодова А.А., Злоказова М.В. Этиопатогенез расстройств аутистического спектра: современные аспекты проблемы. Вятский медицинский вестник. 2015; 2: 25-8. [Bezgodova A.A., Zlokazova M.V. Etiopathogenesis of autism spectrum disorders: contemporary aspects of the problem. Vyatka Medical Bulletin. 2015; 2; 25-8. (in Russian)]
  10. Замалеева Р.С., Лазарева В.К., Черепанова И.А., Фризина А.В., Железова М.Е. Современные представления о влиянии регуляторных аутоантител на развитие гестационного процесса. Практическая медицина. 2013; 7: 63-6. [Zamaleeva R.S., Lazarev K.V., Cherepanova N.A., Frizina A.V., Zhelezova M.E. Modern views on the impact of regulatory autoantibodies for the development of gestational process. Prakticheskaya meditsina. 2013; 7: 63-66. (in Russian)]
  11. CDC (Centers for Disease Control and Prevention). Prevalence of autism spectrum disorders - autism and developmental disabilities monitoring network, 14 sites, United States. 2008. MMWR Surveill. Summ. 2012; 61: 1-19.
  12. Полетаев А.Б., Полетаева А.А., Пухаленко А.И., Замалеева Р.С., Черепанова Н.А., Фризин Д.В. Адаптивные иммунные реакции матери и формирование расстройств аутистического спектра у ребенка. Вестник Санкт-Петербургского университета. Медицина. 2015; 4: 99-113. [Poletaev A.B., Poletaeva A.A., Pukhalenko A.I., Zamaleeva R.S., Cherepanova N.A., Frizin D.V. Adaptive immune response of the mother and the formation of autism spectrum disorders (ASD) in the child. Bulletin of St. Petersburg State University. 2015; 56: 73-80. (in Russian)]
  13. Аутизм в России. Акция Социальный заказ «Статистика 2010-2011» [Электронный ресурс]. Available at: http://www.autisminrussia.ru/3index. htm [Autism in Russia. Action Social order “Statistics 2010-2011” [Electronic resource]. Available at: http://www.autisminrussia.ru/3index. htm (in Russian)]
  14. Полетаев А.Б., Полетаева А.А., Хмельницкая А.В. Иммунохимические признаки изменений в опиатной системе у детей, страдающих аутизмом. Возможные причины и следствия. Клиническая патофизиология. 2016; 1: 48-54. [Poletaev А.В., Poletaeva А.А., Khmelnitskaya A.V. Immunochemical signs of changes in the opiate system in children with autism. Possible causes and consequences. Klinicheskaya patofiziologiya. 2016; 1; 48-54. (in Russian)]
  15. Стародубов В.П., Суханова Л.П. Репродуктивные проблемы демографического развития России. М.: «Менеджер здравоохранения»; 2012. 320с. [Starodubov V.l., Sukhanova L.P. Reproductive problems of demographic development of Russia. Moscow: “Health Manager”; 2012. 320p. (in Russian)]
  16. Савельева Г.М., Шалина Р.И., Панина О.Б., Курцер М.А. Акушерство. М.: ГЭОТАР-Медиа; 2010. 656с. [Savelyeva G.М., Shalina R.I., Panina О.В., KurtserMA. Obstetrics. Moscow: GEOTAR-Media; 2010. 656p. (in Russian)]
  17. Долгушина И.В. Иммунологические аспекты развития плацентарной недостаточности и невынашивания беременности у пациенток с хроническими вирусными инфекциями. Акушерство и гинекология. 2008; 4: 16-9. [Dolgushina N.V. Immunological aspects of the development of placental insufficiency and pregnancy loss in patients with chronic viral infections. Akusherstvo і ginekologiya/Obstetrics and gynecology. 2008; (4): 16-9. (in Russian)]

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2017 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies