Intrauterine infection during pregnancy


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Abstract

Recently, there have been more and more reports on the role of intrauterine infection (IUI) in pregnant women in the occurrence of a wide spectrum of obstetric and perinatal complications. To date, there is no generally accepted terminology for this complication. IUIshould be considered as a spectrum of infectious and inflammatory processes in various placental structures. The diagnosis of IUI during pregnancy presents significant difficulties. IUI can be verified only on the basis of placental morphological examination. In this connection, this diagnosis is made mainly retrospectively after the related complications have occurred. At the present stage, the search for non-invasive markers of subclinical IUI is being continued. Much attention is paid to the peculiarities of the course of pregnancy, ultrasound signs, and the study of immune factors. The treatment of IUI is no less difficult than its diagnosis. Recent publications on the pathogenesis, diagnosis, and treatment of IUI during pregnancy are reviewed. Conclusion. Despite the clinical significance of the problem of IUI during pregnancy, there is still no algorithm that allows for a comprehensive approach to diagnostic and therapeutic measures. The timely diagnosis and reasonable use of antimicrobial drugs can become a promising area in the package of therapeutic measures for the prevention of pregnancy complications and adverse perinatal outcomes in the presence of IUI.

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About the authors

Valentina F. Dolgushina

South Ural Medical University, Ministry of Health of Russia

Email: dolgushinavf@yandex.ru
Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology

Ilona V. Kurnosenko

South Ural Medical University, Ministry of Health of Russia

Email: kurnosenko.ilona@gmail.com
Dr. Med. Sci., Professor of the Department of Obstetrics and Gynecology

Marina V. Astashkina

South Ural Medical University, Ministry of Health of Russia

Email: astashkina-marina83@mail.ru
Assistant Professor, Department of Obstetrics and Gynecology

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