Efficiency analysis of IVF programs with the use of «Ural'skaya odnoshagovaya» Ural-m-1step culture medium
- Authors: Komarova Е.M.1, Kazakova I.A.2, Lisovskaya T.V.2, Ivanov A.V.3, Mayasina E.N.2, Kozhevnikova A.I.2, Ivanov I.V.4, Fedoseeva O.B.4, Vartanyan E.V.5,6,7, Levin V.A.8, Gzgzyan A.M.1, Kogan I.Y.1
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Affiliations:
- D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology
- Clinical Institute of Reproductive Medicine LLC
- City Mariinsky Hospital
- All-Russian Research and Testing Institute of Medical Equipment of Roszdravnadzor
- N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
- SRO “Association of ART Clinics"
- ART Clinic "Test Tube Children" LLC
- Ornament Health AG
- Issue: No 8 (2025)
- Pages: 172-178
- Section: Original Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/690424
- DOI: https://doi.org/10.18565/aig.2025.194
- ID: 690424
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Abstract
The procedures of the embryological stage of in vitro fertilization (IVF) program mainly determine the effectiveness of this technology for infertility treatment. Currently, in Russia it is possible to buy culture media for IVF programs from various manufacturers.
Objective: To assess the effectiveness of IVF programs with the use of "Ural'skaya odnoshagovaya" Ural-m-1step culture medium (TU 21.20.23–001–47571069–2022), LLC "Incammedic" (Russia).
Materials and methods: Two study groups were formed: the main group, which included 240 sibling IVF and IVF/ICSI protocols, with fertilization and embryo cultivation carried out on the Ural-m-1step medium (Russia), and comparison group, which consisted of 240 sibling IVF and IVF/ICSI protocols, with fertilization and embryo cultivation performed on the Vitrolife line of media (Sweden). To stimulate ovulation in patients of both groups we used protocols with GnRH antagonists; to support the luteal phase, a micronized progesterone preparation (Iprozhin, Italfarmaco, Italy/France) was introduced at a dose of 600 mg per day in 2 doses vaginally.
In the main group, 119 embryo transfers into the uterine cavity were performed on the 5th–6th day of cultivation, whereas the comparison group included 103 embryo transfers.
Results: According to the key quality indicators adopted by the Vienna and the Maribor consensuses, the effectiveness of IVF programs using the compared media did not statistically differ, p>0.05. The percentage of fertilization, the proportion of blastocysts, the number of blastocysts of excellent quality obtained on the 5th–6th day of cultivation in IVF and IVF/ICSI cycles in the main and comparison groups also did not differ. The pregnancy/implantation rate corresponded to the target ones, according to the Vienna and the Maribor consensuses, and did not have significant differences in the main and comparison groups, both in “fresh” cycles: 57/119 (54.8%) and 47/103 (48.8%), respectively, p=0.338, and in cryoprotocols: 62/119 (58.8%) and 56/103 (59.6%), respectively, p=0.660.
Conclusion: The results of the study indicate that the outcomes of IVF programs performed with in combination with the Ural-m-1step medium (TU 21.20.23–001–47571069–2022), LLC "Incammedik" (Russia), are comparable to those using the Vitrolife media (Sweden), which proves the interchangeability of these medical products in clinical practice.
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About the authors
Е. M. Komarova
D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology
Email: evgmkomarova@gmail.com
ORCID iD: 0000-0002-9988-9879
PhD (Bio), Junior Researcher, embryologist, ART Department
Russian Federation, St. PetersburgI. A. Kazakova
Clinical Institute of Reproductive Medicine LLC
Email: brykina_irina@mail.ru
PhD (Bio), Head of the Clinical Embryology Laboratory
Russian Federation, YekaterinburgT. V. Lisovskaya
Clinical Institute of Reproductive Medicine LLC
Author for correspondence.
Email: tv.lis@mail.ru
ORCID iD: 0000-0002-9747-9323
Dr. Med. Sci., Associate Professor, Deputy Director General for Scientific and Methodological Work
Russian Federation, YekaterinburgA. V. Ivanov
City Mariinsky Hospital
Email: dr.ivanovav@gmail.com
Head of Assisted Reproductive Technologies Department
Russian Federation, St. PetersburgE. N. Mayasina
Clinical Institute of Reproductive Medicine LLC
Email: elena.mayasina@gmail.com
ORCID iD: 0000-0002-3387-819X
PhD, Deputy Director General for Medical Unit
Russian Federation, YekaterinburgA. I. Kozhevnikova
Clinical Institute of Reproductive Medicine LLC
Email: kkozhhh@yandex.ru
embryologist assistant
Russian Federation, YekaterinburgI. V. Ivanov
All-Russian Research and Testing Institute of Medical Equipment of Roszdravnadzor
Email: ministr38@gmail.com
ORCID iD: 0000-0003-0971-853X
Dr. Med. Sci., General Director
Russian Federation, MoscowO. B. Fedoseeva
All-Russian Research and Testing Institute of Medical Equipment of Roszdravnadzor
Email: fob18-fob18@rambler.ru
Lecturer at the Center for Scientific Research and Advanced Development
Russian Federation, MoscowE. V. Vartanyan
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia; SRO “Association of ART Clinics"; ART Clinic "Test Tube Children" LLC
Email: emma-vartanyan@mail.ru
ORCID iD: 0000-0003-0337-086X
Dr. Med. Sci., Professor, Department of Obstetrics and Gynecology, President, Director
Russian Federation, Moscow; Moscow; MoscowV. A. Levin
Ornament Health AG
Email: vitalylevin0205@gmail.com
ORCID iD: 0009-0000-8758-0842
endocrinologist, specialist in the organization of health and public health
Switzerland, LucerneA. M. Gzgzyan
D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology
Email: agzgzyan@mail.ru
ORCID iD: 0000-0003-3917-9493
Dr. Med. Sci., Professor, Head of the ART Department
Russian Federation, St. PetersburgI. Yu. Kogan
D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology
Email: ikogan@mail.ru
ORCID iD: 0000-0002-7351-6900
Dr. Med. Sci., Professor, Corresponding Member of RAS, Director
Russian Federation, St. PetersburgReferences
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