PROGNOSTIC VALUE OF THE DETERMINATION OF INTERLEUKINS 6, 8, AND TUMOR NECROSIS FACTOR-?? IN THE SERUM AND AMNIOTIC FLUID OF PATIENTS WITH EARLY AMNIORRHEA

Objective. To study the level of interleukin (IL)-6, IL-8, and tumor necrosis factor-а (TNF-а) in the serum and amniotic fluid of patients with early amniorrhea (EA) while pursuing an active wait-and-see policy. Subjects and methods. A study group comprised 68 patients with EA and full-term pregnancy, without severe obstetric and somatic abnormalities; a control group consisted of 29 patients with full-term pregnancy and timely amniorrhea. The serum and amniotic fluid levels of IL-6, IL-8, and TNF-а were once measured in the patients of both groups during their delivery. Results. As compared to the control group, the study group was found to have a statistically signif icant increase in the peripheral blood serum levels of IL-8 and TNF-а. No IL-6 concentration changes were observed in the compared groups. At the same time there was a correlation between the amniotic fluid levels of IL-8 and TNF-а in the study group women while it was essentially slighter in the control group. The peripheral blood serum showed the reverse. Conclusion. The cytokines play an important role in the mechanisms of pathogenesis of EA. The equal concentration of IL-6 in the peripheral blood serum and amniotic fluids in the compared groups may suggest that there is no risk for pyoseptic complications when pursuing the active wait-and-see policy proposed by the authors for EA in the women selected in accordance with the above criteria.

-8, early amniorrhea, full-term pregnancy, interleukins-6, -8, active wait-and-see policy