Systemic inflammation and insulin resistance in the pathogenesis of polycystic ovary syndrome
- Авторлар: Rasin M.S.1, Zhitnik V.P.2
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Мекемелер:
- Internal Medicine Department № 3
- Poltava City Maternity Hospital
- Шығарылым: № 8 (2015)
- Беттер: 26-32
- Бөлім: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247466
- ID: 247466
Дәйексөз келтіру
Аннотация
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of ch ildbearing age, which affects 5-7% of the population and is associated with a broad spectrum of diseases: hypertension, dyslipidemia (DL), atherosclerosis, type 2 diabetes mellitus (T2DM), and gestational diabetes, increased risk of myocardial infarction, stroke, and higher cardiovascular and overall mortality rates. Inflammation, insulin resistance (IR), and hyperinsulinemia are permanent components of the pathogenesis of PCOS in obese women and in the majority of normal weight women due to the presence of a multitude of factors initiating systemic inflammation (SI) and IR. Metformin (MF) and pioglitasone (PG) are the only drugs that reduce SI and IR in different ways, which themselves used alone or in combination with hormonal agents make it possible to restore ovulation, fertility, and pregnancy carrying in 90% of the women, by minimizing the need for surgical intervention, as well as to prevent, stop, and ensure the regression of T2DM, dyslipidemia, non-alcoholic fatty liver disease, atherosclerosis, and hypertension. The administration of MF is completely safe and limited only by an individual’s intolerance that is mainly associated with gastrointestinal disorders. PG treatment requires monitoring the state of the bladder, eyeground, and bone mineral density due to rare changes in these organs and tissues.
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Авторлар туралы
Mikhail Rasin
Internal Medicine Department № 3MD, professor
Vladislav Zhitnik
Poltava City Maternity Hospitaldoctor of the highest category, an obstetrician-gynecologist
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