NONCLASSIC CONGENITAL ADRENAL HYPERPLASIA IN THE PRACTICE OF AN OBSTETRICIAN/GYNECOLOGIST
- Авторлар: Grodnitskaya E.E.1, Kurtser M.A.2
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Мекемелер:
- Center for Family Planning and Reproduction, Moscow Healthcare Department
- N.I. Pirogov Russian National Research Medical University
- Шығарылым: № 5 (2016)
- Беттер: 33-37
- Бөлім: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247620
- ID: 247620
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Аннотация
Objective. To carry out a systems analysis of the data available in the current literature on the prevalence, etiopathogenesis, diagnosis, and therapy of nonclassic congenital adrenal hyperplasia (NCAH). Material and methods. The review includes the foreign and Russian publications available in the Pubmed database on this topic. The search depth was 15 years. Results. The paper describes the principles of steroidogenesis in the adrenal cortex in NCAH. It presents the molecular genetic bases of 21-hydroxylase deficiency. An update on the epidemiology, etiology, pathogenesis, clinical picture, and treatment of NCAH is given. Conclusion. The specific treatment of NCAH should be individual and be performed in accordance with the clinical manifestations of the disease and a woman’s reproductive purposes. By taking into account problems in diagnosing NCAH, glucocorticoid therapy should be commenced only if there are solid grounds. The diagnosis of NCAH may be finally verified by molecular genetic testing and the mutations being found in the CYP21 gene.
Толық мәтін
Авторлар туралы
Elena Grodnitskaya
Center for Family Planning and Reproduction, Moscow Healthcare Department
Email: elena1778@mail.ru
MD, PhD, obstetrician-gynecologist, consultative and diagnostic department Moscow 117209, Sevastopolsky prospect, 24A, Russia
Mark Kurtser
N.I. Pirogov Russian National Research Medical University
Email: agpf.gms@gmail.com
MD, PhD, Professor, Correspondent Member of RAS Moscow 117209, Sevastopolsky prospect, 24A, Russia
Әдебиет тізімі
- Петеркова В.А., Семичева Т.В., Духарева О.В., Колесникова Г.С., Карева М.А., Прокофьев С.А., Яровая И.С., Солдатова Т.В., Пнафилова Е.В., Васюкова О.В. Диагностика и лечение синдрома гиперандрогении у девочек-подростков. Методические рекомендации. М.; 2005: 5-7.
- Карева М.А., Чугунов И.С. Федеральные клинические рекомендации - протоколы по ведению пациентов с врожденной дисфункцией коры надпочечников в детском возрасте. Проблемы эндокринологии. 2014; 60(2): 42-50.
- Trapp C.M., Oberfield S.E. Recommendations for treatment of nonclassic congenital adrenal hyperplasia (NCCAH): an update. Steroids. 2012; 77(4): 342-6. doi: 10.1016/j.steroids.2011.12.009.
- Witchel S.F., Azziz R. Nonclassic congenital adrenal hyperplasia. Int. J. Pediatr. Endocrinol. 2010; 2010: 625105.
- Аносова Т.А. Анализ распространенности неклассической формы дефицита 21-гидроксилазы в российской популяции и клинико-гормональные особенности заболевания у детей раннего возраста: дисс.. канд. мед. наук. М.; 2015. 162с.
- Azziz R., Sanchez L.A., Knochenhauer E.S., Moran C., Lazenby J., Stephens K.C. et al. Androgen excess in women: experience with over 1000 consecutive patients. J. Clin. Endocrinol. Metab. 2004; 89(2): 453-62.
- Escobar-Morreale H.F., Sanchon R., San Millân J.L. A prospective study of the prevalence of nonclassical congenital adrenal hyperplasia among women presenting with hyperandrogenic symptoms and signs. J. Clin. Endocrinol. Metab. 2008; 93(2): 527-33.
- Unluhizarci K., Kula M., Dundar M., Tanriverdi F., Israel S., Colak R. et al. The prevalence of non-classic adrenal hyperplasia among Turkish women with hyperandrogenism. Gynecol. Endocrinol. 2010; 26(2): 139-43.
- Гродницкая Е.Э., Курцер М.А. Частота неклассической формы врожденной дисфункции коры надпочечников, связанной с недостаточностью 21-гидроксилазы, среди женщин с гиперандрогенией. Проблемы репродукции. 2011; 17(1): 46-9.
- Moran C., Azziz R., Weintrob N., Witchel S.F., Rohmer V., Dewailly D. et al. Reproductive outcome of women with 21-hydroxylase-deficient nonclassic adrenal hyperplasia. J. Clin. Endocrinol. Metab. 2006; 91(9): 3451-6.
- Dewailly D. Nonclassic 21-hydroxylase deficiency. Semin. Reprod. Med. 2002; 20(3): 243-8.
- Speiser P.W., Azziz R., Baskin L.S., Ghizzoni L., Hensle T.W., Merke D.P. et al.; Endocrine Society. Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 2010; 95(9): 4133-60.
- Martin K.A., Chang R.J., Ehrmann D.A., Ibanez L., Lobo R.A., Rosenfield R.L. et al. Evaluation and treatment of hirsutism in premenopausal women: an endocrine society clinical practice guideline. J. Clin. Endocrinol. Metab. 2008; 93(4): 1105-20.
- Whitney K.M., Ditre C.M. Management strategies for acne vulgaris. Clin. Cosmet. Investig Dermatol. 2011; 4: 41-53.
- Arowojolu A.O., Gallo M.F., Lopez L.M., Grimes D.A. Combined oral contraceptive pills for treatment of acne. Cochrane Database Syst. Rev. 2012. Jun 13; 6: CD004425.
- Palombo-Kinne E., Schellschmidt I., Schumacher U., Gräser T. Efficacy of a combined oral contraceptive containing 0.030 mg ethinylestradiol/2 mg dienogest for the treatment of papulopustular acne in comparison with placebo and 0.035 mg ethinylestradiol/2 mg cyproterone acetate. Contraception. 2009; 79(4): 282-9.
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