NONCLASSIC CONGENITAL ADRENAL HYPERPLASIA IN THE PRACTICE OF AN OBSTETRICIAN/GYNECOLOGIST
- 作者: Grodnitskaya E.E.1, Kurtser M.A.2
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隶属关系:
- Center for Family Planning and Reproduction, Moscow Healthcare Department
- N.I. Pirogov Russian National Research Medical University
- 期: 编号 5 (2016)
- 页面: 33-37
- 栏目: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247620
- ID: 247620
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详细
Objective. To carry out a systems analysis of the data available in the current literature on the prevalence, etiopathogenesis, diagnosis, and therapy of nonclassic congenital adrenal hyperplasia (NCAH). Material and methods. The review includes the foreign and Russian publications available in the Pubmed database on this topic. The search depth was 15 years. Results. The paper describes the principles of steroidogenesis in the adrenal cortex in NCAH. It presents the molecular genetic bases of 21-hydroxylase deficiency. An update on the epidemiology, etiology, pathogenesis, clinical picture, and treatment of NCAH is given. Conclusion. The specific treatment of NCAH should be individual and be performed in accordance with the clinical manifestations of the disease and a woman’s reproductive purposes. By taking into account problems in diagnosing NCAH, glucocorticoid therapy should be commenced only if there are solid grounds. The diagnosis of NCAH may be finally verified by molecular genetic testing and the mutations being found in the CYP21 gene.
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作者简介
Elena Grodnitskaya
Center for Family Planning and Reproduction, Moscow Healthcare Department
Email: elena1778@mail.ru
MD, PhD, obstetrician-gynecologist, consultative and diagnostic department Moscow 117209, Sevastopolsky prospect, 24A, Russia
Mark Kurtser
N.I. Pirogov Russian National Research Medical University
Email: agpf.gms@gmail.com
MD, PhD, Professor, Correspondent Member of RAS Moscow 117209, Sevastopolsky prospect, 24A, Russia
参考
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