Vitamin K-dependent protein periostin as a new marker for the quality of oocytes and embryos, and the effectiveness of assisted reproductive technologies program
- Авторлар: Khechumyan L.R.1, Kalinina E.A.1, Burmenskaya O.V.1, Donnikov A.E.1, Kulakova E.V.1
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Мекемелер:
- National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov
- Шығарылым: № 4 (2018)
- Беттер: 72-76
- Бөлім: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/248164
- DOI: https://doi.org/10.18565/aig.2018.4.72-76
- ID: 248164
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Аннотация
Objective. To assess the role of the vitamin K-dependent protein periostin as a marker for the quality of oocytes and embryos and the outcome of an IVF/ICSI program. Subjects and methods. The investigation enrolled 100 women who were eligible for inclusion. In accordance with the results of infertility treatment, the investigators formed two study groups: 1) 28 patients with a successful treatment outcome, of whom two patients were found to have a biochemical pregnancy; 2) 72 patients with a negative treatment result. All the women underwent determination of mean follicular fluid level of periostin and its mRNA expression in the epithelial cells of the cervical canal. Results. A correlation was shown between the follicular fluid level of periostin and the quality of oocytes and embryos. The group of women who had immature oocytes showed an association of the follicular fluid level of periostin and its mRNA expression in the epithelial cells of the cervical canal with incipient pregnancy (28%) after an IVF/ICSI program. Conclusion. The high follicular fluid level of periostin in the patients who had immature oocytes among those retrieved using the IVF/ICSI program is a predictive criterion of success of the program, which may reflect a relationship between the level of periostin and the degree of oocyte maturity.
Толық мәтін
Авторлар туралы
Lusine Khechumyan
National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov
Email: khechumyan_l@mail.ru
graduate student of department of assisted reproductive technology in treating sterility
Elena Kalinina
National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov
Email: e_kalinina@oparina4.ru
MD, Associate Professor, The chief of department of assisted reproductive technology in treating sterility
Olga Burmenskaya
National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov
Email: o_bourmenskaya@oparina4.ru
PhD, DSc, Senior Researcher of Molecular-Genetics Department
Andrew Donnikov
National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov
Email: a_donnikov@oparina4.ru
PhD, Senior Researcher of molecul-genetical laboratory
Elena Kulakova
National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov
Email: evkulakova@mail.ru
PhD, Senior Researcher of department of assisted reproductive technology in treating sterility
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